Protein Alignment Ptx1 and PAX4

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_001353039.1
• Gene: PAX4 / 5078
• HGNCID: 8618
• Length: 351
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 72/319 - (22%)
• Similarity: 104/319 - (32%)
• Gaps: 125/319 - (39%)

  Fly   208 QTSSTSSISNRSRDRKDGNRSVNETTIKTENISS----SGHDEPMTTSGEEPKNDKKNKRQRRQR 268
            :|.|.||| ||.......::.:..|.:::..:.:    :.|....|..|..|....:|      |
Human   117 KTPSVSSI-NRVLRALQEDQGLPCTRLRSPAVLAPAVLTPHSGSETPRGTHPGTGHRN------R 174

  Fly   269 THFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRERNAMNAAVAA 333
            |.|:..|.:.||..|.|.:|||...|.::|..|:|.|..|||||.|||||||::|:
Human   175 TIFSPSQAEALEKEFQRGQYPDSVARGKLATATSLPEDTVRVWFSNRRAKWRRQEK--------- 230

  Fly   334 ADFKSGFGTQFMQPFADDSLYSSYPYNNWTKVPSPLGTKPFPWPVNPLGSMVAGNHHQNSVNCFN 398
                  ...:...|.|...|          .||.
Human   231 ------LKWEMQLPGASQGL----------TVPR------------------------------- 248

  Fly   399 TGASGVAVSMNNASMLPGSMGSSLSNTSNVGAVGAPCPYTTPANPYMYR----SAAEPCMS---- 455
                 ||..:.:|...|||:.:            |..|...|..|..|:    :|.|.|:|
Human   249 -----VAPGIISAQQSPGSVPT------------AALPALEPLGPSCYQLCWATAPERCLSDTPP 296

  Fly   456 ---------------SSMSSSIATLRLKAKQHASAGFGSPYSAPSPVSRSNSAGLSACQ 499
                           :|:.|.:..|                  |.|.|..:.|.||..|
Human   297 KACLKPCWGHLPPQPNSLDSGLLCL------------------PCPSSHCHLASLSGSQ 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	27/55 (49%)
PAX4	NP_001353039.1	PAX	5..129	CDD:128645	7/12 (58%)
		Homeodomain	172..227	CDD:459649	28/60 (47%)