DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptx1 and pitx3

DIOPT Version :9

Sequence 1:	NP_001138130.2	Gene:	Ptx1 / 43664	FlyBaseID:	FBgn0020912	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_991238.1	Gene:	pitx3 / 402974	ZFINID:	ZDB-GENE-041229-4	Length:	293	Species:	Danio rerio

Alignment Length:	321	Identity:	146/321 - (45%)
Similarity:	178/321 - (55%)	Gaps:	61/321 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 NFQTSSTSSISNRSRDRKDGNRSVNETTIKTENISSSGHDEPMTTSGEEPKNDKKNKRQRRQRTH 270
            :|...:.|...:.:....|.....::...|.::.|.:.......|....|::....|:|||||||
Zfish     2 DFNLLTDSEARSPALSLSDSGTPQHDPGCKGQDNSDTEKSHQNHTDESNPEDGSLKKKQRRQRTH 66

  Fly   271 FTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRERNAMNAAVAAAD 335
            ||||||||||.||.||||||||||||||:||||||||||||||||||||||||||..     |..
Zfish    67 FTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQ-----AEL 126

  Fly   336 FKSGFGTQF---MQPFADDSLYSSYPYNNW-TK--VPSPLGTKPFPW----PVNPLGSMVAGNHH 390
            .|:|||.||   |||:  |.:||.|.|||| ||  ..|||..|.||:    .|:||.|.
Zfish   127 CKNGFGAQFNGLMQPY--DDMYSGYSYNNWATKSLASSPLSAKSFPFFNSMNVSPLSSQ------ 183

  Fly   391 QNSVNCFNTGASGVAVSMNNA-SMLP----GSMGSSLSNTSNVGAVGAP-----------CPYTT 439
                ..|:..:|  ..|||.| ||:|    |..||.|:|..|:..:.:|           |||.|
Zfish   184 ----PMFSPPSS--IPSMNMASSMVPSAVAGVPGSGLNNLGNLNNLNSPTLNSAAVSAAACPYAT 242

  Fly   440 PANPYMYRSAAEPCMSSSMSSSIATLRLKAKQHASAGFGSPYSAPSPVSRSNSAGLSACQY 500
            .|.|||||   :.|     :||:|:|||||||||:  |..| :..:|||     .||.|||
Zfish   243 TAGPYMYR---DTC-----NSSLASLRLKAKQHAN--FAYP-AVQNPVS-----NLSPCQY 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeobox	268..320	CDD:278475	48/51 (94%)
pitx3	NP_991238.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..69		16/66 (24%)
		Cnd2	18..>79	CDD:303063	23/60 (38%)
		Homeobox	64..116	CDD:278475	48/51 (94%)
		OAR	251..268	CDD:281777	11/21 (52%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	255..268		10/12 (83%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O35160	260..264		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3550
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1432356at2759
OrthoFinder	1	1.000	-	-		FOG0001767
OrthoInspector	1	1.000	-	-		otm26409
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45882
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	9.070