Protein Alignment Ptx1 and PHOX2A

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_001412025.1
• Gene: PHOX2A / 401
• HGNCID: 691
• Length: 312
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 84/275 - (30%)
• Similarity: 110/275 - (40%)
• Gaps: 81/275 - (29%)

  Fly   254 EPKNDKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARV---------- 308
            ||....:.::|||.||.|||.||:|||..|:...|||:.||||:|:..:||||||
Human    80 EPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQDLTRALRPR 144

  Fly   309 ------------------RVWFKNRRAKWRKRERNA-MNAAVAAADFKSGFGTQFMQPFADDSLY 354
                              :|||:|||||:||:||.| ...|..||..|.|......:.  |||..
Human   145 ADPVRSPTLVQADWPLCPQVWFQNRRAKFRKQERAASAKGAAGAAGAKKGEARCSSED--DDSKE 207

  Fly   355 SSYPYNNWTKVPSPLGTKPFPWPVNPLGSMVAGNHHQNSVNCFNTGASGVAVSMNNASMLPGSMG 419
            |       |..|:|..|...|.|..|                      |:|....:.|.||.::|
Human   208 S-------TCSPTPDSTASLPPPPAP----------------------GLASPRLSPSPLPVALG 243

  Fly   420 SSLSNTSNVGAVGAPCPYTTPANPYMYRSAAEPCMSSSMSSSIATLRLKAKQHASAGFGSPYSA- 483
            |.          ..|.|...|....::...|.. ......:..|.| |||.|.|.:|.| |:|.
Human   244 SG----------PGPGPGPQPLKGALWAGVAGG-GGGGPGAGAAEL-LKAWQPAESGPG-PFSGV 295

  Fly   484 -------PSPVSRSN 491
                   |.|..::|
Human   296 LSSFHRKPGPALKTN 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	35/83 (42%)
PHOX2A	NP_001412025.1	Homeodomain	91..175	CDD:459649	35/83 (42%)