DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptx1 and eyg

DIOPT Version :9

Sequence 1:	NP_001138130.2	Gene:	Ptx1 / 43664	FlyBaseID:	FBgn0020912	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_001014582.1	Gene:	eyg / 39419	FlyBaseID:	FBgn0000625	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	729	Identity:	153/729 - (20%)
Similarity:	233/729 - (31%)	Gaps:	263/729 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TALGPGGLTNGGGGVVSGALNGLEAMSAESTGLCLQDLVSAGTANGA-GSAGSAESATTTSTALS 89
            |:|.|...:.....|.:.|.....|.:|           :||..:|| ...|.|.|.:.||..:.
  Fly    36 TSLAPHASSVAAASVAAAAAAAAAAAAA-----------AAGAGSGAVAGGGGATSTSPTSVQIP 89

  Fly    90 SGSTGSSTVNGGGSSTSGTEH------------LHSHHSL----------------HDSSSSVSI 126
            .|.       |||.||.|..|            |.|.|.|                |..:...::
  Fly    90 PGF-------GGGGSTGGIPHGAGGPTGSTLNTLMSQHRLLEFSRFGGLRGYDIAQHMLTQQGAV 147

  Fly   127 SPAISSLMP----------------------------------------------------ISSL 139
            |..:.||.|                                                    :||:
  Fly   148 SKLLGSLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSSI 212

  Fly   140 SHLHHSAGQDLV--------------------GGYSQHPHHTV-----VPPHTPKHEPLEKLRIW 179
            :.:..:...:.|                    |.::.||...|     |||..|   |.....:.
  Fly   213 NRILRNRAAERVATEFARTAAYGLYPPPPHPYGSFTWHPAGNVPGGQGVPPPPP---PSALWSVA 274

  Fly   180 AET-GDFRDSHSSMTAVA--NSLDSTHLNNFQTSSTSSISNRSRDRKDGNRSVNETTIKTENISS 241
            |.| .:...|.:|...|:  .||.|.||.......|.  :||:.....|:....|:..:..:|.|
  Fly   275 APTLANLPPSAASAVPVSTCGSLSSAHLMAGGAGGTP--TNRAISPGSGSHDTLESADENRHIDS 337

  Fly   242 SGHDEPMTTSGEEPKNDKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEA 306
            ...|:     .:|||       .||.||.|:.:||:|||..|.::.||.:||||.::..|:|:||
  Fly   338 DYLDD-----DDEPK-------FRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEA 390

  Fly   307 RVRVWFKNRRAKWRKRERNAMNAAVAAADFKSGFGTQFMQPFADDSLYSSYPYNNWTKVPSPLGT 371
            ||:|||.|||||||:.:|  ||.....   :|..........::|:..||...:|.:...:....
  Fly   391 RVQVWFSNRRAKWRRHQR--MNLLKRQ---RSSPANPLHSQQSNDAPASSPTPSNHSSASTSAPV 450

  Fly   372 KPFPWP--------------------VNPLGSMVAGNHHQNSVNCFNTGASGVAVSMNNASMLPG 416
            .|.|.|                    ::||.....|:||.:.::                  ||
  Fly   451 APVPPPQQPLPLCGDHSPQGPPPSVLLHPLHGPPGGHHHHHPLH------------------LP- 496

  Fly   417 SMGSSLSNTSNVGAVGAPCPYTTPA-----------------NPYMYRSAAEPCMSSSMSSSIAT 464
                                 |.||                 ..:..:..........:|.|...
  Fly   497 ---------------------THPAALQLLSHYHQQQQQQQQQQHQQQQQQHHQQQQQLSPSGCN 540

  Fly   465 LRLKAKQHASAG-----FGSPYSAPSPVSRSNSAGLSACQYTGVGVTDVVXENALGALLN--QHQ 522
               .|..|.|.|     |.|..|:|           ||..:.|     :. :.|:.|.|.  :.|
  Fly   541 ---PAANHLSMGGERSAFRSLVSSP-----------SAAAFLG-----LARQYAVAASLTVAEEQ 586

  Fly   523 HHLQHFSGGSVG----GSGVPNGMQQHSGNMLHHSNLGLDHSDLGLVGGGPSNHQDEGNHSLEGS 583
            ....|:|.|.:|    |:|......|..|:.:...|...|..:       ..|..|:.:..:|.|
  Fly   587 RSRLHYSAGGLGSGGEGTGPNTNTTQSGGSTMTVDNSSSDSDE-------EINVHDDSDGEIESS 644

  Fly   584 NKSPMEAPLANSSN 597
            ..:..:....:||:
  Fly   645 AATAAKVARLSSSD 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeobox	268..320	CDD:278475	29/51 (57%)
eyg	NP_001014582.1	HTH	120..217	CDD:304362	9/96 (9%)
eyg	NP_001014582.1	Homeobox	352..404	CDD:278475	29/51 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450804
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840