Protein Alignment Ptx1 and EVX2

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_001073927.1
• Gene: EVX2 / 344191
• HGNCID: 3507
• Length: 476
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 135/588 - (22%)
• Similarity: 206/588 - (35%)
• Gaps: 169/588 - (28%)

  Fly    33 LTNGGGGVVSGALNGLEAMSAESTGLCLQDLVSAGTANGAGSAGSAESATTTSTALSSGSTGS-S 96
            |:|..|..|      |||:........|...:.:...:.|.....|:......|..:...||| |
Human    28 LSNSAGNAV------LEALENSQHPARLSPRLPSAPLHSALGELPAKGKFEIDTLFNLQHTGSES 86

  Fly    97 TVNGGGSSTSGTEHLHSHHS----LHDSSSSVSISPAISSLMPISSL--SHLHHSAGQDLVGGYS 155
            ||:...||.:.:.....|:|    ..|.||.|.:  ..|:|.....|  :.|..:.|:    ||
Human    87 TVSSEISSAAESRKKPGHYSEAAAEADMSSDVEV--GCSALRSPGGLGAAQLKENNGK----GY- 144

  Fly   156 QHPHHTVVPPHTPKHEPLEKLRIWAETGDFRDSHSSMTAVANSLDSTHLNNFQTSSTSSISNRSR 220
                                    ||:|....:.:|  |..:.|.|.|..:..:..::::..
Human   145 ------------------------AESGSAAGTTTS--ASGSGLGSLHGGSGGSGGSAALGG--- 180

  Fly   221 DRKDGNRSVNETTIKTENISSSGHDEPMTTSGEEPKNDKKNKRQRRQRTHFTSQQLQELEHTFSR 285
                               |.||.|:                 .||.||.||.:|:..||..|.|
Human   181 -------------------SGSGADQ-----------------VRRYRTAFTREQIARLEKEFYR 209

  Fly   286 NRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRERNAMNAAVAAADFKSGFGTQFMQPFAD 350
            ..|.....|.|:|...||.|..::|||:|||.| .||:|.||:               :..| ||
Human   210 ENYVSRPRRCELAAALNLPETTIKVWFQNRRMK-DKRQRLAMS---------------WPHP-AD 257

  Fly   351 DSLYSSYPYNNWTKVPSPLGTKPFPWPVN-PLGSMVAGNHHQNSVNCFNTGASGVAVSMNNASML 414
            .|.| :|...:    .:..|:.|:|:..: ||       |:...|..  |.|:..|.:...|:..
Human   258 PSFY-TYMMTH----AAATGSLPYPFHSHVPL-------HYYPHVGV--TAAAAAAAASGAAAAA 308

  Fly   415 PGSMGSSLSNTSNVGAVGAPCPYTTP------ANPYMYRS-AAEPCMSSSMSSSIATLRLKAKQH 472
            .....:|:.......|:..  ||:.|      .:|.:|:: ||...::|:.|::.|.....|...
Human   309 SSPFATSIRPLDTFRALSH--PYSRPELLCSFRHPGLYQAPAAAAGLNSAASAAAAAAAAAAAAS 371

  Fly   473 ASAGFGSPYSAPS-PVS-----RSNSAGLSACQYTGVGVTDVVXENALGALLNQHQHHLQHFSGG 531
            ::|..|:|.|..| |.|     .|.||..:|          .. ..|||:          ...||
Human   372 SAAAAGAPPSGGSAPCSCLSCHSSQSAAAAA----------AAAAAALGS----------RGGGG 416

  Fly   532 SVGGSGVPNGMQQHSGNMLHHSNLGLDHSDLGLVGGGPSNHQDEGNHSLEGSNKSPM-------E 589
            ..||.|...|....:|.          .||.|.....|.:......:|....:|:.:       |
Human   417 GGGGGGGGGGGGAGAGG----------GSDFGCSAAAPRSESGFLPYSAAVLSKTAVSPPDQRDE 471

  Fly   590 APL 592
            |||
Human   472 APL 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	25/55 (45%)
EVX2	NP_001073927.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..113		10/30 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..185		12/95 (13%)
		Homeodomain	189..245	CDD:459649	25/56 (45%)