Protein Alignment Ptx1 and HHEX

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_002720.1
• Gene: HHEX / 3087
• HGNCID: 4901
• Length: 270
• Species: Homo sapiens
• Alignment Length: 288
• Identity: 57/288 - (19%)
• Similarity: 87/288 - (30%)
• Gaps: 123/288 - (42%)

  Fly    53 AESTGLCLQDLVSAGTANGAGSAGSAESATTTSTALSSGSTGSSTVNGGGSSTSGTEHLHSHHSL 117
            |..|...::|::..|.|          :.|...|..|..|:.:|.|:...:.......:|
Human    27 AHPTPFYIEDILGRGPA----------APTPAPTLPSPNSSFTSLVSPYRTPVYEPTPIH----- 76

  Fly   118 HDSSSSVSISPAISSLMPISSLSHLHHSAGQDLVGGYSQ-------HPHHTVVPPHTP---KHEP 172
                      ||.|           ||||.. |...|..       :|....|..:|.   :|:|
Human    77 ----------PAFS-----------HHSAAA-LAAAYGPGGFGGPLYPFPRTVNDYTHALLRHDP 119

  Fly   173 LEKLRIWAETGDFRDSHSSMTAVANSLDSTHLNNFQTSSTSSISNRSRDRKDGNRSVNETTIKTE 237
            |.|..:|:
Human   120 LGKPLLWS--------------------------------------------------------- 127

  Fly   238 NISSSGHDEPMTTSGEEPKNDKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTN 302
                     |..   :.|.:.:|..:.|     |::.|..|||..|...:|.....|:.:|....
Human   128 ---------PFL---QRPLHKRKGGQVR-----FSNDQTIELEKKFETQKYLSPPERKRLAKMLQ 175

  Fly   303 LTEARVRVWFKNRRAKWR--KRERNAMN 328
            |:|.:|:.||:|||||||  |:|....|
Human   176 LSERQVKTWFQNRRAKWRRLKQENPQSN 203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	22/57 (39%)
HHEX	NP_002720.1	Interaction with SOX13. /evidence=ECO:0000269|PubMed:20028982	1..137		31/215 (14%)
		Homeodomain	136..194	CDD:459649	22/62 (35%)
		Required for WNT signaling induction. /evidence=ECO:0000269|PubMed:20028982	137..270		26/72 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..270		3/10 (30%)