DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptx1 and pitx2

DIOPT Version :9

Sequence 1:	NP_001138130.2	Gene:	Ptx1 / 43664	FlyBaseID:	FBgn0020912	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_571050.1	Gene:	pitx2 / 30164	ZFINID:	ZDB-GENE-990714-27	Length:	314	Species:	Danio rerio

Alignment Length:	388	Identity:	162/388 - (41%)
Similarity:	203/388 - (52%)	Gaps:	97/388 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 ISSLMPISSLSHLHHSAGQDLVGGYSQHPHHTVVPPHTPKHEPLEKLRIWAETGDFRDSHSSMTA 194
            ::|:....||.|.||:             ||..    ..||.||...             ||:..
Zfish     1 MTSMKDPLSLDHHHHN-------------HHVT----GSKHAPLSMA-------------SSLQP 35

  Fly   195 VANSLDSTHLNNFQTSSTSSISNRSRDRKDGNRSVNETTIKTENISSSGHDEPMTTSGEEPKNDK 259
            :..|:||.|..:..|.|.:| |..|.:::.| :|.||          ..:|:|           .
Zfish    36 LQRSVDSKHRLDVHTVSDTS-SPESVEKEKG-QSKNE----------DSNDDP-----------S 77

  Fly   260 KNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRER 324
            |.|||||||||||||||||||.||.||||||||||||||:|||||||||||||||||||||||||
Zfish    78 KKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRER 142

  Fly   325 NAMNAAVAAADFKSGFGTQF---MQPFADDSLYSSYPYNNWTK---VPSPLGTKPFPW----PVN 379
            |..     |...|:|||.||   |||:  |.:|.||.||||..   ..:.|.||.||:    .||
Zfish   143 NQQ-----AELCKNGFGPQFNGLMQPY--DDMYPSYTYNNWAAKGLTSASLSTKSFPFFNSMNVN 200

  Fly   380 PLGSMVAGNHHQNSVNCFNTGASGVAVSMNNASMLPGSMGSSLSNTSNV-------GAVGAPCPY 437
            ||.|....: ..||::..:..:|.|..::..   :|||..:||:|.:|:       |.....|||
Zfish   201 PLSSQTMFS-PPNSISSMSMSSSMVPSAVTG---VPGSSLNSLNNLNNLSNPSLNSGVPTPACPY 261

  Fly   438 TTPANPYMYRSAAEPCMSSSMSSSIATLRLKAKQHASAGFGSPYSAPSPVSRSNSAGLSACQY 500
            ..|..||:||   :.|     :||:|:||||||||:|.|:.   |..:|.|     .||||||
Zfish   262 APPTPPYVYR---DTC-----NSSLASLRLKAKQHSSFGYA---SVQNPAS-----NLSACQY 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeobox	268..320	CDD:278475	48/51 (94%)
pitx2	NP_571050.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93		42/144 (29%)
		Homeobox	86..138	CDD:278475	48/51 (94%)
		OAR	272..289	CDD:281777	11/21 (52%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	276..289		10/12 (83%)
		Nuclear localization signal. /evidence=ECO:0000255	282..286		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55454
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3550
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1432356at2759
OrthoFinder	1	1.000	-	-		FOG0001767
OrthoInspector	1	1.000	-	-		otm26409
orthoMCL	1	0.900	-	-		OOG6_107540
Panther	1	1.100	-	-	O	PTHR45882
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3409
SonicParanoid	1	1.000	-	-		X469
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.000