Protein Alignment Ptx1 and Pitx3

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_062120.1
• Gene: Pitx3 / 29609
• RGDID: 3332
• Length: 302
• Species: Rattus norvegicus
• Alignment Length: 282
• Identity: 123/282 - (43%)
• Similarity: 153/282 - (54%)
• Gaps: 68/282 - (24%)

  Fly   252 GEEPKNDKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRR 316
            |..|::....|:|||||||||||||||||.||.||||||||||||||:|||||||||||||||||
  Rat    50 GGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRR 114

  Fly   317 AKWRKRERNAMNAAVAAADFKSGFGTQFMQPFADDSLYSSYPYNNW--TKVPSPLGTKPFPWPVN 379
            |||||||| :..|.:....|.:..| ..:.|:  :.:|..|.|.||  ..:..||..|.||:..|
  Rat   115 AKWRKRER-SQQAELCKGGFAAPLG-GLVPPY--EEVYPGYTYGNWPPKALAPPLAAKTFPFAFN 175

  Fly   380 -----PLGSMVAGNHHQNSVNCFNTGASGVAVSMNNASMLPGSMGSSLSNTSNVGAV----GAP- 434
                 ||.|...          |:..:|..|..:.:|:..||::       ...||:    |||
  Rat   176 SVNVGPLASQPV----------FSPPSSIAASMVPSAAAAPGTV-------PGPGALQGLGGAPP 223

  Fly   435 -------------CPYTTPA--------NPYMYRSAAEPCMSSSMSSSIATLRLKAKQHASAGFG 478
                         |||.:.|        :||:||   :||     :||:|:||||||||||  |.
  Rat   224 GLAPAAVSSGAVSCPYASAAAAAAAAASSPYVYR---DPC-----NSSLASLRLKAKQHAS--FS 278

  Fly   479 SPYSAPSPVSRSNSAGLSACQY 500
            .| :.|.|...:|   ||.|||
  Rat   279 YP-AVPGPPPAAN---LSPCQY 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	52/55 (95%)
Pitx3	NP_062120.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		11/20 (55%)
		Homeodomain	63..119	CDD:459649	52/55 (95%)
		PTZ00395	<142..>236	CDD:185594	26/112 (23%)
		OAR	258..275	CDD:461067	12/21 (57%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275		10/12 (83%)
		Nuclear localization signal. /evidence=ECO:0000255	268..272		3/3 (100%)