Protein Alignment Ptx1 and Alx1

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_001408403.1
• Gene: Alx1 / 216285
• MGIID: 104621
• Length: 377
• Species: Mus musculus
• Alignment Length: 382
• Identity: 103/382 - (26%)
• Similarity: 143/382 - (37%)
• Gaps: 135/382 - (35%)

  Fly   165 PHTPKHEPLEKLRIWAETGDFRDS--HSSMTAVANSLDSTHL-------NNFQTSSTSSISNRSR 220
            |....|..|::      |...:||  :..:|.|......|.|       ||.:.|....:..:|.
Mouse    57 PRAEHHVRLDR------TSPCQDSSVNYGITKVEGQPLHTELNRAMDNCNNLRMSPVKGMPEKSE 115

  Fly   221 DRKDGNRSVNETTIKTENISSSGHDEPMTTSGEEPKNDKKNKRQRRQRTHFTSQQLQELEHTFSR 285
            ..:.|::.       ..|:|||                    ::||.||.|||.||:|||..|.:
Mouse   116 LDELGDKC-------DSNVSSS--------------------KKRRHRTTFTSLQLEELEKVFQK 153

  Fly   286 NRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRERNAMNAAVAAADFKSGFGTQF---MQP 347
            ..|||:..||::|:.|.||||||:|||:|||||||||||...     ....||.|...:   :.|
Mouse   154 THYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQ-----IQQAKSHFAATYDISVLP 213

  Fly   348 FADDSLYSSYPY---NNWT------------KVPSPLGTKPFPWPVNPL--GSMVAGNHHQNSVN 395
            ..|     |||.   |.|.            .:|....:...|:..:|.  .|....::|||..:
Mouse   214 RTD-----SYPQIQNNLWAGNASGGSVVTSCMLPRDASSCMTPYSHSPRTDSSYTGFSNHQNQFS 273

  Fly   396 CFNTGASGVAVSMNN---ASMLPGSMGSSLSNTSNVGAVGAPCPYTTPANPYMYRSAAEPCMSSS 457
                     .|.:||   .|:|.|:                       .|.:.:.:..|   ...
Mouse   274 ---------HVPLNNFFTDSLLTGA-----------------------TNGHAFETKPE---FER 303

  Fly   458 MSSSIATLRLKAKQHAS-----------------------AGFGSPYSAPSPVSRSN 491
            .|||||.||:|||:|.:                       |||  ..|.|||....|
Mouse   304 RSSSIAVLRMKAKEHTANISWAMFDITVHSLLPGQCLHIPAGF--LLSHPSPPGLMN 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	35/55 (64%)
Alx1	NP_001408403.1	Homeodomain	133..189	CDD:459649	35/55 (64%)
		Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q63087	192..326		37/178 (21%)
		OAR	302..320	CDD:461067	11/17 (65%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	306..319		9/12 (75%)