Protein Alignment Ptx1 and EVX1

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_001980.1
• Gene: EVX1 / 2128
• HGNCID: 3506
• Length: 407
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 98/435 - (22%)
• Similarity: 158/435 - (36%)
• Gaps: 139/435 - (31%)

  Fly   139 LSHLHHSAGQDLVGGYSQHPHHTV---------VPPHT-------PKHEPLEKLRIWAETGDFRD 187
            :|:|..:.|..|    .:.|...|         |||.|       |:.||::.| ..:..|...:
Human    24 VSNLSEAVGSPL----PEPPEKMVPRGCLSPRAVPPATRERGGGGPEEEPVDGL-AGSAAGPGAE 83

  Fly   188 SHSSMTAV------ANSLD--------------STHLNNFQTSSTSSISNRSRDRKDGNRSVNET 232
            ...:..|:      |.|:|              |......:.|.|...:..:.:.:....|.:|.
Human    84 PQVAGAAMLGPGPPAPSVDSLSGQGQPSSSDTESDFYEEIEVSCTPDCATGNAEYQHSKGSGSEA 148

  Fly   233 TIKTENISSSGHDEPMTTSGEEPKNDK------KNKRQRRQRTHFTSQQLQELEHTFSRNRYPDM 291
            .:.:.|   .|.:.|.:..|......:      .:.:.||.||.||.:|:..||..|.|..|...
Human   149 LVGSPN---GGSETPKSNGGSGGGGSQGTLACSASDQMRRYRTAFTREQIARLEKEFYRENYVSR 210

  Fly   292 STREEIAMWTNLTEARVRVWFKNRRAKWRKRERNAMNAAVAAADFKSGFGTQFMQPFADDSLYS- 355
            ..|.|:|...||.|..::|||:|||.| .||:|.||.               :..| ||.:.|:
Human   211 PRRCELAAALNLPETTIKVWFQNRRMK-DKRQRLAMT---------------WPHP-ADPAFYTY 258

  Fly   356 -----------SYPYNNWTKVP--SPLG----------TKPFPWPVNPLGS--MVAGNHHQNSVN 395
                       .||:.:...:|  ||:|          ..||...:.||.:  :::..:.:..:.
Human   259 MMSHAAAAGGLPYPFPSHLPLPYYSPVGLGAASAASAAASPFSGSLRPLDTFRVLSQPYPRPELL 323

  Fly   396 CFNTGASGVAVSMNNASMLPG---SMGSSLSNTSNVGAVGAPCP----YTTPANPYMYRSAAE-- 451
            |          :..:..:.||   .:|:|         .|.||.    ::.|||....|:||.
Human   324 C----------AFRHPPLYPGPAHGLGAS---------AGGPCSCLACHSGPANGLAPRAAAASD 369

  Fly   452 -PCMSSSMSSSIATLRLKAKQHASAGFGSPYSAPSPVSRSNSAGL 495
             .|.|:|.|.|..|.                 |||.:|:::|..|
Human   370 FTCASTSRSDSFLTF-----------------APSVLSKASSVAL 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	25/55 (45%)
EVX1	NP_001980.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..120		18/95 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	137..179		6/44 (14%)
		Homeodomain	184..240	CDD:459649	25/56 (45%)