Protein Alignment Ptx1 and Pax4

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_035168.1
• Gene: Pax4 / 18506
• MGIID: 97488
• Length: 349
• Species: Mus musculus
• Alignment Length: 249
• Identity: 63/249 - (25%)
• Similarity: 91/249 - (36%)
• Gaps: 82/249 - (32%)

  Fly   211 STSSISNRSRDRKDGNRSVNETTIKTENISS----SGHDEPMTTSGEEPKNDKKNKRQRRQRTHF 271
            |.||| ||.......::|::.|.:::..:.:    |.|.......|..|....:|      ||.|
Mouse   120 SVSSI-NRVLRALQEDQSLHWTQLRSPAVLAPVLPSPHSNCGAPRGPHPGTSHRN------RTIF 177

  Fly   272 TSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRERNAMNAAVAAAD- 335
            :..|.:.||..|.|.:|||...|.::|..|:|.|..|||||.|||||||::|:....|.:..|.
Mouse   178 SPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWRRQEKLKWEAQLPGASQ 242

  Fly   336 -------------------------------FKSGF-----GT------------QFMQPFAD-D 351
                                           ....|     ||            .::||:.| .
Mouse   243 DLTVPKNSPGIISAQQSPGSVPSAALPVLEPLSPSFCQLCCGTAPGRCSSDTSSQAYLQPYWDCQ 307

  Fly   352 SLY----SSYPYNNWTKVPSPLGTKPFPWP---VNPLGSMVAGNHHQNSVNCFN 398
            ||.    |||              ..|.||   .:|:..::.|.....|.:|.|
Mouse   308 SLLPVASSSY--------------VEFAWPCLTTHPVHHLIGGPGQVPSTHCSN 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	27/55 (49%)
Pax4	NP_035168.1	PAX	5..129	CDD:128645	6/9 (67%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	8..64
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	83..131		6/11 (55%)
		Homeodomain	172..227	CDD:459649	28/60 (47%)
		Transcription repression	278..349		19/84 (23%)