Protein Alignment Ptx1 and DLX2

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_004396.1
• Gene: DLX2 / 1746
• HGNCID: 2915
• Length: 328
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 100/473 - (21%)
• Similarity: 152/473 - (32%)
• Gaps: 183/473 - (38%)

  Fly    85 STALSSGST---GSSTVNGGGSSTSGTEHLHSHHSLHDSSSSVSI-SPAISSLMPISS------L 139
            ||.:::.||   .....:|||:...|           :||||.|: .|..|..:|:|:      .
Human    14 STQIAASSTYHQHQQPPSGGGAGPGG-----------NSSSSSSLHKPQESPTLPVSTATDSSYY 67

  Fly   140 SHLHHSAGQDLVGGYSQHPHHTVVPPHTPKHEPLEKLRIWAETGDFRDSHSSMTAVANSLDSTHL 204
            ::..|.||.   ||....|                    :|..|.::...|.:..|..|..|::.
Human    68 TNQQHPAGG---GGGGGSP--------------------YAHMGSYQYQASGLNNVPYSAKSSYD 109

  Fly   205 NNFQTSST--------SSISNRSRDRKDGNRSVNETTIKTENISSSGHDEPMTTSGEEPKNDKKN 261
            ..:..:.|        ||.:|...:::|     .|..|:..|                    .|.
Human   110 LGYTAAYTSYAPYGTSSSPANNEPEKED-----LEPEIRIVN--------------------GKP 149

  Fly   262 KRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRERNA 326
            |:.|:.||.::|.||..|:..|.:.:|..:..|.|:|....||:.:|::||:|||:|::|.
Human   150 KKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKM---- 210

  Fly   327 MNAAVAAADFKSGFGTQFMQPFADDSLYSSYPYNNWTKVPSPLGTKPFPWPVNPLGSMVAGNHHQ 391
                     :|||.......|.|..|          ....||..:.|..|.......|..|...
Human   211 ---------WKSGEIPSEQHPGASAS----------PPCASPPVSAPASWDFGVPQRMAGGGGP- 255

  Fly   392 NSVNCFNTGASGVAVSMNNASMLPGSMGSSLSNTSNVGAVGAPCPYTTPANPYMYRSAAEPCMSS 456
                  .:|.||.           ||.|||.|:.::......|..:.|
Human   256 ------GSGGSGA-----------GSSGSSPSSAASAFLGNYPWYHQT----------------- 286

  Fly   457 SMSSSIATLRLKAKQHASAGFGSPYSAPSPVSRSNSAGLSACQYTGVGVTDVVXENALGALLNQH 521
              |.|.:.|:      |:|....|...|.|                                  |
Human   287 --SGSASHLQ------ATAPLLHPTQTPQP----------------------------------H 309

  Fly   522 QHHLQHFSGGSVGGSGVP 539
            .||..|      ||.|.|
Human   310 HHHHHH------GGGGAP 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	21/55 (38%)
DLX2	NP_004396.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..81		20/78 (26%)
		DLL_N	51..132	CDD:463567	19/103 (18%)
		Homeodomain	153..209	CDD:459649	21/55 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..270		20/86 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..328		11/62 (18%)