DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptx1 and NOBOX

DIOPT Version :10

Sequence 1:NP_001138130.2 Gene:Ptx1 / 43664 FlyBaseID:FBgn0020912 Length:610 Species:Drosophila melanogaster
Sequence 2:NP_001073882.3 Gene:NOBOX / 135935 HGNCID:22448 Length:691 Species:Homo sapiens


Alignment Length:450 Identity:92/450 - (20%)
Similarity:142/450 - (31%) Gaps:204/450 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly   203 HLNNFQTSSTSSISNRSRDRKDGNRSVNETTIKTENISSSGHDEPMTTSGEEPKNDKKNKRQRRQ 267
            ||.|.  .||.:.||::||.|.|                    .|..|.          :.:::.
Human   243 HLANL--LSTLAQSNQNRDHKQG--------------------PPEVTC----------QIRKKT 275

  Fly   268 RTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVR----------------------- 309
            ||.:.|.||:|||..|..:.|||...|.|||....:|..|:.                       
Human   276 RTLYRSDQLEELEKIFQEDHYPDSDKRREIAQTVGVTPQRIMVKGAGSLVAGWSGGGPTIETLEL 340

  Fly   310 ---------VWFKNRRAKWRKRERNAMN--------AAVAAADFKSGFGTQFM---------QPF 348
                     |||:||||||||.|:  :|        ||...|..:.....:.:         .||
Human   341 QSERSAVAWVWFQNRRAKWRKMEK--LNGKESKDNPAAPGPASSQCSSAAEILPAVPMEPKPDPF 403

  Fly   349 ADDSLYSSYP------YNNWTKVPS------------PLGTKP------FPWPVNPLGSM----- 384
            ..:|...::|      .::.|..|:            ||.:.|      .|:|:.|:.:.     
Human   404 PQESPLDTFPEPPMLLTSDQTLAPTQPSEGAQRVVTPPLFSPPPVRRADLPFPLGPVHTPQLMPL 468

  Fly   385 ---VAG--NHHQNSVNCFNTGASGVAVSMNNASMLPGSMGSSLSNTSNVGAVGAPCPY------- 437
               |||  :.|::. .|                   ||.|:|::       :..||.|       
Human   469 LMDVAGSDSSHKDG-PC-------------------GSWGTSIT-------LPPPCSYLEELEPQ 506

  Fly   438 ----TTPANPYMYRSAAEPCMSSSMSSSIATLRLKAKQHASAGFGSPYSAPSPVSRSNSAGLSAC 498
                :....|:.:..|.:|.:..|....:..|..           .|:|.||.::          
Human   507 DYQQSNQPGPFQFSQAPQPPLFQSPQPKLPYLPT-----------FPFSMPSSLT---------- 550

  Fly   499 QYTGVGVTDVVXENALGALLNQHQHHLQHFSGGSVGGS------GVPNG---MQQHSGNM 549
                               |...:..|..|..|..||:      |..:|   ||..:||:
Human   551 -------------------LPPPEDSLFMFPCGPSGGTSQGYCPGASSGQILMQPPAGNI 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptx1NP_001138130.2 Homeodomain 265..321 CDD:459649 27/87 (31%)
NOBOXNP_001073882.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 94..233
Homeodomain 273..361 CDD:459649 27/87 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 366..385 4/18 (22%)
PHA03247 <374..646 CDD:223021 48/284 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 394..437 6/42 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 635..691
Blue background indicates that the domain is not in the aligned region.

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