DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptx1 and Pitx1

DIOPT Version :9

Sequence 1:	NP_001138130.2	Gene:	Ptx1 / 43664	FlyBaseID:	FBgn0020912	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_446076.1	Gene:	Pitx1 / 113983	RGDID:	69253	Length:	315	Species:	Rattus norvegicus

Alignment Length:	362	Identity:	147/362 - (40%)
Similarity:	188/362 - (51%)	Gaps:	92/362 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 PPHTPKHEPLEKLRIWAETGDFRDSHSSMTAVANSLDSTHLNNFQTSSTSSISNRSRDRKDGNRS 228
            ||..|.|:......: |.|.|.|:.               |.|  ::|.||.::.....:.|...
  Rat    19 PPPPPPHDMGPSFHL-ARTADPREP---------------LEN--SASESSDADLPDKERGGEAK 65

  Fly   229 VNETTIKTENISSSGHDEPMTTSGEEPKNDKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMST 293
            |.|         ..|.......|.|:|   .|.|:|||||||||||||||||.||.||||||||.
  Rat    66 VPE---------DGGAGSAGCGSAEDP---AKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSM 118

  Fly   294 REEIAMWTNLTEARVRVWFKNRRAKWRKRERNAMNAAVAAADF-KSGFGTQF---MQPFADDSLY 354
            |||||:||||||.|||||||||||||||||||..      .|. |.|:..||   :||:.|....
  Rat   119 REEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQ------LDLCKGGYVPQFSGLVQPYEDVYAA 177

  Fly   355 SSYPYNNW---TKVPSPLGTKPFPW--PVNPLGSMVAGNHHQNSVNCFNTGASGVAVSMNNASML 414
            :.|.||||   :..|:||.||.|.:  .::||.|.          :.|:..:|..:::| .:||.
  Rat   178 AGYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQ----------SMFSAPSSISSMTM-PSSMG 231

  Fly   415 PGSM---------------GSSLSNTSNVGAVGAPCPYTTPANPY-MYRSAAEPCMSSSMSSSIA 463
            |||:               ||||::..:.||    |||.|||:|| :||   :.|     :||:|
  Rat   232 PGSVPGMPNSGLNNINNLTGSSLNSAMSPGA----CPYGTPASPYSVYR---DTC-----NSSLA 284

  Fly   464 TLRLKAKQHASAGFGSPYSAPSPVSRSNSAGLSACQY 500
            :||||:|||:|.|:|   ....|.|     ||:||||
  Rat   285 SLRLKSKQHSSFGYG---GLQGPAS-----GLNACQY 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeobox	268..320	CDD:278475	46/51 (90%)
Pitx1	NP_446076.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103		35/113 (31%)
		Homeobox	93..146	CDD:395001	47/52 (90%)
		Interaction with PIT-1. /evidence=ECO:0000250	149..280		49/159 (31%)
		OAR	277..294	CDD:397759	10/21 (48%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	281..294		9/12 (75%)
		Nuclear localization signal. /evidence=ECO:0000255	287..291		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5806
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1432356at2759
OrthoFinder	1	1.000	-	-		FOG0001767
OrthoInspector	1	1.000	-	-		otm44736
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45882
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X469
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.020