DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and CYP721A1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_177649.1	Gene:	CYP721A1 / 843850	AraportID:	AT1G75130	Length:	505	Species:	Arabidopsis thaliana

Alignment Length:	560	Identity:	125/560 - (22%)
Similarity:	219/560 - (39%)	Gaps:	122/560 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 FLLGSILIFLV---VYN------KRRSRLVKYIEKIPGPAAMPFLGNAIEMN------------- 74
            |:|..:..|||   :|:      :.:|...|  :.:.||:...|.||:.|::
plant     5 FILVLVFFFLVFRFIYSNIWVPWRIQSHFKK--QSVTGPSYRIFSGNSGEVSRLTAEAKSKPIPS 67

  Fly    75 -----------VDHDELFNRVIGMQKLWGTRIGINRVWQGTAPRVLLFEPETV-EPILNSQKFVN 127
                       ..|...::||.|...|:         |.|:.|.|...:|..: |.:.....|..
plant    68 GRNPHEFVHRVAPHYHEWSRVYGKTFLY---------WFGSKPVVATSDPRLIREALTTGGSFDR 123

  Fly   128 KSHD------YDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARK-- 184
            ..|:      |       .:||......:|...|:|...||..:.|..::......:.:|..|
plant   124 IGHNPLSKLLY-------AQGLPGLRGDQWAFHRRIAKQAFTMEKLKRWVPQMVTSTMMLMEKWE 181

  Fly   185 --------LAVEVGSEAFNLFPYVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSR 241
                    :.:||..|..||       :.:::..||.|..:        |..|.::.:    |.|
plant   182 DMRNGGEEIELEVHKEMHNL-------SAEMLSRTAFGNSV--------EEGKGIFEL----QER 227

  Fly   242 QAKIWLQSDFIFSLTAEYKLHQS-YINTLHGFSNMVIR-----ERKAELAILQENNNNNNNNAPD 300
            ..:::            |.:..| ||.....|.:...|     |::..::||:...||..
plant   228 MMRLF------------YLVRWSVYIPGFRFFPSKTNREIWRIEKQIRVSILKLIENNKT----- 275

  Fly   301 AYDDVGKKKRL--AFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPE 363
               .|.|...|  ||:....:.:.:...|..|::.:|..||.|...:||:..:::.|.||..:.|
plant   276 ---AVEKSGTLLQAFMSPYTNQNGQEEKLGIEEVTDECKTFYFAAKETTANLMTFVLVLLAMNQE 337

  Fly   364 YQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVP 428
            :|....||:..:.|  :....|:..|.|::.|...|.::|||:|....:.|...:...:|...:|
plant   338 WQNIAREEVICVLG--QTGLPTLDILQDLKTLSMIINETLRLYPPAMTLNRDTLKRAKLGDLDIP 400

  Fly   429 AGTQAIIMTYALHRNPRVF-PKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEK 492
            ||||..:...|:|.:...: ...|:|||..|....   :.....:||..|||.|:||..|:.|.|
plant   401 AGTQLYLSVVAMHHDKETWGDDAEEFNPRRFEDPK---KQSALLVPFGLGPRTCVGQNLAVNEAK 462

  Fly   493 AVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVKIT 532
            .|::|:|:.|............:| .:.|:|::|..:..|
plant   463 TVLATILKYYSFRLSPSYAHAPVL-FVTLQPQNGAHLLFT 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	116/521 (22%)
CYP721A1	NP_177649.1	p450	26..495	CDD:386267	117/531 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950