DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and CYP86A2

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_191946.1	Gene:	CYP86A2 / 828019	AraportID:	AT4G00360	Length:	553	Species:	Arabidopsis thaliana

Alignment Length:	547	Identity:	132/547 - (24%)
Similarity:	229/547 - (41%)	Gaps:	86/547 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVI-GMQKLWGT--- 93
            ||.:::....::.:|.||.:|      ||...|.||:...:....|.:.:.:. .::...||
plant     8 LLVAVVAAYWLWFQRISRWLK------GPRVWPVLGSLPGLIEQRDRMHDWITENLRACGGTYQT 66

  Fly    94 ---RIGINRVWQGTAPRVLLFEPETVEPILNSQKFVN--KSHDYD-YLHPWLGEGLLTSTDRKWH 152
               .:......||..  .:..:|:.:|.:|.: :|.|  |...:. ..|.:||:|:..|....|.
plant    67 CICAVPFLAKKQGLV--TVTCDPKNIEHMLKT-RFDNYPKGPTWQAVFHDFLGQGIFNSDGDTWL 128

  Fly   153 SRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGS---EAFNLFPYVTLCTLDIVCETAMG 214
            .:||.....|..:.|...:..:..:...|.....:|...   |..:|...:...|.|.:|..|.|
plant   129 FQRKTAALEFTTRTLRQAMGRWVNRGIKLRFCPILETAQNNYEPVDLQDLILRLTFDNICGLAFG 193

  Fly   215 R--RIYAQSNSESEYVKAVYGIGSIVQSR--------QAKIWLQSDFIFSLTAEYKLHQSYINTL 269
            :  |..|....|:.:..|..........|        :.|.||      .|..|..|.:| :..:
plant   194 KDTRTCAPGLPENGFASAFDRATEASLQRFILPEFLWRLKKWL------GLGLEVSLSRS-LGEI 251

  Fly   270 HGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIRE 334
            .|:.:.||..||.||...:|:....::   |......|||         |.|...|.|     |.
plant   252 DGYLDAVINTRKQELLSQRESGVQRHD---DLLSRFMKKK---------DQSYSETFL-----RH 299

  Fly   335 EVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKET--------PATMKNLMD 391
            ....|:..|.||:|.|:||..:|:..||..::::|.|:.|:..:.:.|        |.....:..
plant   300 VALNFILAGRDTSSVALSWFFWLITTHPTVEDKIVREICSVLIETRGTDVSSWTAEPLEFDEVDR 364

  Fly   392 MRYLECCIKDSLRLFPSVPMMAR-MVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFP------K 449
            :.||:..:.::|||:||||..:: :|.:|:...|..||||:......||..|....:.      |
plant   365 LVYLKAALSETLRLYPSVPEDSKHVVNDDILPDGTFVPAGSSVTYSIYAAGRMKSTWGEDCLEFK 429

  Fly   450 PEQF-NPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKI-----EAVD 508
            ||:: :||:   ........:.::.|:||||.|:|:..|.|:.|.:.:.||.::::     ..|:
plant   430 PERWISPDD---GKFVNHDQYRFVAFNAGPRICLGKDLAYLQMKTIAAAVLLRHRLTVAPGHKVE 491

  Fly   509 RREDLTLLGELILRPKDGLRVKITPRD 535
            ::..|||.      .|:||.|.:..||
plant   492 QKMSLTLF------MKNGLLVNVHKRD 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	124/515 (24%)
CYP86A2	NP_191946.1	CYP86A	67..504	CDD:410687	113/472 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1194
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920