DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and CYP704A2

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_182075.1	Gene:	CYP704A2 / 819159	AraportID:	AT2G45510	Length:	511	Species:	Arabidopsis thaliana

Alignment Length:	537	Identity:	132/537 - (24%)
Similarity:	246/537 - (45%)	Gaps:	74/537 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TVFLLGSILIFLV--VYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVIGMQKLWG 92
            |:|::....|:|:  ::..:.....:|         .|......::....|||::        :.
plant    14 TIFIVLCFTIYLMIRIFTGKSRNDKRY---------APVHATVFDLLFHSDELYD--------YE 61

  Fly    93 TRIGINR-VWQGTAP---RVLLFEPETVEPILNSQKFVNKSHDY---DYLHPWLGEGLLTSTDRK 150
            |.|...: .::..:|   .:|..:|..||.||.: :|.|.|..:   :.:...||.|:......|
plant    62 TEIAREKPTYRFLSPGQSEILTADPRNVEHILKT-RFDNYSKGHSSRENMADLLGHGIFAVDGEK 125

  Fly   151 WHSRRKILTPAFHFKILDDF-IDVFNEQSAVLARKLA-VEVGSEAFNLFPYVTLCTLDIVCETAM 213
            |..:||:.:..|..::|.|| ..||...::.|...:: ..:..:||:....:..||||.:.:...
plant   126 WRQQRKLSSFEFSTRVLRDFSCSVFRRNASKLVGFVSEFALSGKAFDAQDLLMRCTLDSIFKVGF 190

  Fly   214 G---RRIYAQSNSESEYVKAVYGIGSIVQSRQ--AKIWLQSDFIFSLTAEYKLHQSYINTLHGFS 273
            |   :.:...|....|:::| :..|::..|.:  ..:| :..:.|::.::.||.:| |.|:..|.
plant   191 GVELKCLDGFSKEGQEFMEA-FDEGNVATSSRFIDPLW-KLKWFFNIGSQSKLKKS-IATIDKFV 252

  Fly   274 NMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVDT 338
            ..:|..::.|||  :|.|.       ...:|:..:       .|:::.|:...::::.:|:.:..
plant   253 YSLITTKRKELA--KEQNT-------VVREDILSR-------FLVESEKDPENMNDKYLRDIILN 301

  Fly   339 FMFEGHDTTSAAISWTLFLLGCHPEYQERVVEEL-DSIFGDDKETPA-------TMKNLMDMRYL 395
            ||..|.|||:|.:||.|::|..:|..||::|:|: |..|..:|.|..       ..:.|.:|.||
plant   302 FMIAGKDTTAALLSWFLYMLCKNPLVQEKIVQEIRDVTFSHEKTTDVNGFVESINEEALDEMHYL 366

  Fly   396 ECCIKDSLRLFPSVPMMARMV-GEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPK-PEQFNPDNF 458
            ...:.::|||:|.||:..|.. .:||...|..|..|.....:.||:.|...::.: .|:|.|:.:
plant   367 HAALSETLRLYPPVPVDMRCAENDDVLPDGHRVSKGDNIYYIAYAMGRMTYIWGQDAEEFKPERW 431

  Fly   459 L------PENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLG 517
            |      ||:     ||.:|.|.||||.|:|:.||..:.|.|...:|..::.:..|....:....
plant   432 LKDGLFQPES-----PFKFISFHAGPRICLGKDFAYRQMKIVSMALLHFFRFKMADENSKVYYKR 491

  Fly   518 ELILRPKDGLRVKITPR 534
            .|.|....||.:...||
plant   492 MLTLHVDGGLHLCAIPR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	125/501 (25%)
CYP704A2	NP_182075.1	PLN03195	15..509	CDD:215627	131/536 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm1194
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920