DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001003947.1	Gene:	Cyp4x1 / 81906	MGIID:	1932403	Length:	507	Species:	Mus musculus

Alignment Length:	516	Identity:	162/516 - (31%)
Similarity:	253/516 - (49%)	Gaps:	56/516 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVIGMQKLWGTRI 95
            ||.|..:|:..:....||.||::.:...|||.|...||:...:..|:.|..:.::.....
Mouse    19 VFCLALVLMQAMKLYLRRQRLLRDLSPFPGPPAHWLLGHQKFLQEDNMETLDEIVKKHPC----- 78

  Fly    96 GINRVWQGTAPRVL-LFEPETVEPILNSQKFVNKSHDYDYLH----PWLGEGLLTSTDRKWHSRR 155
             ....|.|...... :::|:..:..|:     .......|||    |.:|.|||.....:|...|
Mouse    79 -AFPCWVGPFQAFFYIYDPDYAKIFLS-----RTDPKMQYLHQLLTPCIGRGLLNLDGPRWFQHR 137

  Fly   156 KILTPAFHFKILDDFIDVFNEQSAVL---------ARKLAVEVGSEAFNLFPYVTLCTLDIVCET 211
            .:||||||..||...:|.......|:         .::..:||       |.::.|.||||:.:.
Mouse   138 CLLTPAFHQDILKPCVDTMAHSVKVMLDKWEKMWTTQETTIEV-------FEHINLMTLDIIMKC 195

  Fly   212 AMGRRIYAQSNSESE-YVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNM 275
            |.|:....|.|...| ||||.:.:|.|:.||....|...|.||.|:.:....|.....:|.::..
Mouse   196 AFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQYTEK 260

  Fly   276 VIRERKAEL--AILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEG-TVLSNEDIREEVD 337
            :|::||..|  .:.|::...:.                .|||:::.|..|. ...|:.|:|.||:
Mouse   261 IIQDRKKILKNQVKQDDTQTSQ----------------IFLDIVLSAQAEDERAFSDADLRAEVN 309

  Fly   338 TFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDS 402
            |||:.|||.::|:|||.|:.|..:||:|:|...|:.||.||.  :..|.:.|.:|.|...|||::
Mouse   310 TFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDG--SSITWEQLDEMSYTTMCIKET 372

  Fly   403 LRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGR 466
            |||.|.||.::|.:.:.:.: .|..:|||...::..:.||.||.|:..|:.|:|..|..||...|
Mouse   373 LRLIPPVPSISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKENSDQR 437

  Fly   467 HPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGL 527
            ||.|::|||:||||||||:||:||.|..|:.:|..::: |.|...........:||||.|:
Mouse   438 HPCAFLPFSSGPRNCIGQQFAMLELKVAIALILLHFQV-APDLTRPPAFSSHTVLRPKHGI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	154/488 (32%)
Cyp4x1	NP_001003947.1	p450	47..499	CDD:278495	154/488 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750