DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_038935973.1	Gene:	Cyp4f37 / 691312	RGDID:	1585102	Length:	526	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	187/531 - (35%)
Similarity:	282/531 - (53%)	Gaps:	62/531 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 FLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGN--AIEMNVDHDELFNRVIGMQKLWGTR 94
            ::|..||.:...:.:..|||..:.:   .|....|||:  .|:.|.:         |||.:  |.
  Rat    29 WILARILAWTYSFCENCSRLRCFPQ---SPKRNWFLGHLGVIQSNEE---------GMQLV--TE 79

  Fly    95 IG-----INRVWQG-TAPRVLLFEPETVEPILNSQKFVNKSHDYDYLH---PWLGEGLLTSTDRK 150
            :|     ::.:|.| .:|.:.|.:|..|.|:|.:...| ...|..:||   ||||:||..|:..|
  Rat    80 MGQTFRDVHLIWLGPVSPVLRLVDPAFVAPLLQAPALV-APKDPTFLHFLKPWLGDGLFLSSGDK 143

  Fly   151 WHSRRKILTPAFHFKILDDFIDVFNEQSAVLARK---LAVEVGSEAFNLFPYVTLCTLDIVCETA 212
            |...|::|||||||.||..::..||:...::..|   |.:| ||....:|..::|.|||.:.:..
  Rat   144 WSRHRRLLTPAFHFDILKPYVKTFNQSVNIMHAKWKHLCLE-GSARLEMFENISLMTLDSLQKCL 207

  Fly   213 MGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVI 277
            .|.....| .|.|||:.|...:.|:.:.|..|::|..||::..||:.:..:...:.:|.|::.||
  Rat   208 FGFDSNCQ-ESPSEYISATLELSSLTRKRSYKLFLYLDFLYYRTADGQRFRKACDLVHSFTDAVI 271

  Fly   278 RERKAELA------ILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKE-GTVLSNEDIREE 335
            |||:..|:      .|:....:             |.|.|.|:|:|:.|..| |..||:||||.|
  Rat   272 RERRRLLSSQGVDEFLESKTKS-------------KSKTLDFIDVLLLAKDEHGKELSDEDIRAE 323

  Fly   336 VDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIK 400
            .|||||.|||||::|:||.|:.|..|||||||..:|:..:..|.:.......:|..:.:|..|||
  Rat   324 ADTFMFGGHDTTASALSWILYNLASHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLTMCIK 388

  Fly   401 DSLRLF-PSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCA 464
            :||||. |:|.::.|...:.|...|:::|.|...:|..:.:|.||.|:|.||.::|..|.|||..
  Rat   389 ESLRLHPPAVDLLRRCTQDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENRQ 453

  Fly   465 GRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVD---RREDLTLLGELILRPKDG 526
            .|.|.::|||||||||||||.||:.|.|..:...|.:::....|   ||:.     |||||.:.|
  Rat   454 KRSPLSFIPFSAGPRNCIGQTFAMNEVKVAVGLTLLRFRFLPDDKEPRRKP-----ELILRAEGG 513

  Fly   527 --LRVKITPRD 535
              |||::..||
  Rat   514 LWLRVELLSRD 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	179/498 (36%)
Cyp4f37	XP_038935973.1	CYP4F	74..517	CDD:410772	169/465 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348426
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750