DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp4a31

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_964002.2	Gene:	Cyp4a31 / 666168	MGIID:	3028580	Length:	509	Species:	Mus musculus

Alignment Length:	534	Identity:	163/534 - (30%)
Similarity:	279/534 - (52%)	Gaps:	48/534 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LMAESILLSKVGQVISGYSPI-TVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIE 72
            :...::.|::....:||:..: :||.|..:|:..|.....|..|:|.:::.|.|....|.|:  |
Mouse     1 MSVSALSLTRFAGSLSGFLQVASVFCLLLLLVKAVQVYLHRKWLLKALQQFPSPPFHWFFGH--E 63

  Fly    73 MNVDHDELFNRVIGMQK--------LWGTRIGINRVWQGTAPRVLLFEPETVEPIL-NSQKFVNK 128
            ......||...|..::.        .||::..:.           :::|:.::.|| .|....|.
Mouse    64 QFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLT-----------VYDPDYMKVILGRSDPKANG 117

  Fly   129 SHDYDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSE- 192
            :  |..|.||:|.|||....:.|...||:||||||:.||..::....:...::..|.....|.:
Mouse   118 A--YRLLAPWIGYGLLLLNGQSWFQHRKMLTPAFHYDILKTYVKNMADSIRLMLDKWERLAGQDS 180

  Fly   193 AFNLFPYVTLCTLDIVCETAMGRR--IYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSL 255
            :..:|.:::|.|||.|.:.|...:  :....|.:: |::|:..:.::|.||...::.|:|.|:.|
Mouse   181 SIEIFQHISLMTLDTVMKCAFSHKGSVQVDGNYKT-YLQAIGDLNNLVHSRVRNMFHQNDTIYKL 244

  Fly   256 TAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDA 320
            ::..:|........|..::.||:.||.:   ||:.....|         :.||:||.|||:|:.|
Mouse   245 SSNGRLSNQACQLAHDHTDGVIKMRKDQ---LQDEGELEN---------IKKKRRLDFLDILLFA 297

  Fly   321 SKEG-TVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPA 384
            ..|. ..:|::|:|.||||||.||||||::.:||..:.|..|||:|:|..||:.|:.||.  :..
Mouse   298 RMENEDSMSDKDLRAEVDTFMIEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDG--SSI 360

  Fly   385 TMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVFP 448
            |..:|..:.|...|||::|||:|.||.:.|.:...|.. .|..:|.|.|..:..|.||.||:|:|
Mouse   361 TWDHLDQIPYTTMCIKEALRLYPPVPSIGRELSTSVTFPDGCSLPKGVQVTLSIYGLHHNPKVWP 425

  Fly   449 KPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDL 513
            .||.|:|..|.|:  :.||..:::|||.|.|||||::||:.|.|.:::..|.::::.....|..:
Mouse   426 NPEVFDPSRFAPD--SPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPM 488

  Fly   514 TLLGELILRPKDGL 527
            : |...:|:.|:|:
Mouse   489 S-LARFVLKSKNGI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	152/483 (31%)
Cyp4a31	NP_964002.2	p450	52..503	CDD:278495	152/483 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844980
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650