Protein Alignment Cyp4c3 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 179/546 - (32%)
• Similarity: 276/546 - (50%)
• Gaps: 74/546 - (13%)

  Fly    14 ILLSKVGQVISGYSPITVFLLGSILIFLVVY--NKRRSRLVKYIEKIPGPAAMPF---------- 66
            :||..||.          :||..||.:...:  |.||      ::..|.|....:
Human    21 LLLLVVGS----------WLLARILAWTYAFYNNCRR------LQCFPQPPKRNWFWGHLGLITP 69

  Fly    67 ----LGNAIEMNVDHDELFNRVIGMQKLWGTRIGINRVWQG-TAPRVLLFEPETVEPILNSQKFV 126
                |.|:.:|:..:.:.|.                 ||.| ..|.::|..|:|:..|.|:...:
Human    70 TEEGLKNSTQMSATYSQGFT-----------------VWLGPIIPFIVLCHPDTIRSITNASAAI 117

  Fly   127 NKSHD--YDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARK---LA 186
            ....:  ..:|.||||||:|.|...||...|::|||||||.||..:|.:||:.:.::..|   ||
Human   118 APKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLA 182

  Fly   187 VEVGSEAFNLFPYVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDF 251
            .| ||...::|.:::|.|||.:.:.......:.|.. .|||:..:..:.::|:.|...|....||
Human   183 SE-GSSRLDMFEHISLMTLDSLQKCIFSFDSHCQER-PSEYIATILELSALVEKRSQHILQHMDF 245

  Fly   252 IFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLD- 315
            ::.|:.:.:........:|.|::.|||||:..|.         .....|.:.|..|.|.|.|:|
Human   246 LYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLP---------TQGIDDFFKDKAKSKTLDFIDV 301

  Fly   316 LLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDK 380
            ||:...::|..||:||||.|.|||||.|||||::.:||.|:.|..|||||||..:|:..:..|..
Human   302 LLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRD 366

  Fly   381 ETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNP 444
            .......:|..:.:|..|:|:||||.|..|.::|...:|:.: .|:::|.|...:|....:|.||
Human   367 PKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNP 431

  Fly   445 RVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKI--EAV 507
            .|:|.||.::|..|.|||..||.|.|:|||||||||||||.||:.|.|.|::.:|..::.  :..
Human   432 TVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHT 496

  Fly   508 DRREDLTLLGELILRPKDGLRVKITP 533
            :.|..|    |||:|.:.||.:::.|
Human   497 EPRRKL----ELIMRAEGGLWLRVEP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	CYP4V-like	96..529	CDD:410753	161/442 (36%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	165/472 (35%)