Protein Alignment Cyp4c3 and CYP4F12

DIOPT Version :9

• Sequence 1: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 179/546 - (32%)
• Similarity: 276/546 - (50%)
• Gaps: 74/546 - (13%)

  Fly    14 ILLSKVGQVISGYSPITVFLLGSILIFLVVY--NKRRSRLVKYIEKIPGPAAMPF---------- 66
            :||..||.          :||..||.:...:  |.||      ::..|.|....:
Human    21 LLLLVVGS----------WLLARILAWTYAFYNNCRR------LQCFPQPPKRNWFWGHLGLITP 69

  Fly    67 ----LGNAIEMNVDHDELFNRVIGMQKLWGTRIGINRVWQG-TAPRVLLFEPETVEPILNSQKFV 126
                |.|:.:|:..:.:.|.                 ||.| ..|.::|..|:|:..|.|:...:
Human    70 TEEGLKNSTQMSATYSQGFT-----------------VWLGPIIPFIVLCHPDTIRSITNASAAI 117

  Fly   127 NKSHD--YDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARK---LA 186
            ....:  ..:|.||||||:|.|...||...|::|||||||.||..:|.:||:.:.::..|   ||
Human   118 APKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLA 182

  Fly   187 VEVGSEAFNLFPYVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDF 251
            .| ||...::|.:::|.|||.:.:.......:.|.. .|||:..:..:.::|:.|...|....||
Human   183 SE-GSSRLDMFEHISLMTLDSLQKCIFSFDSHCQER-PSEYIATILELSALVEKRSQHILQHMDF 245

  Fly   252 IFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLD- 315
            ::.|:.:.:........:|.|::.|||||:..|.         .....|.:.|..|.|.|.|:|
Human   246 LYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLP---------TQGIDDFFKDKAKSKTLDFIDV 301

  Fly   316 LLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDK 380
            ||:...::|..||:||||.|.|||||.|||||::.:||.|:.|..|||||||..:|:..:..|..
Human   302 LLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRD 366

  Fly   381 ETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNP 444
            .......:|..:.:|..|:|:||||.|..|.::|...:|:.: .|:::|.|...:|....:|.||
Human   367 PKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNP 431

  Fly   445 RVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKI--EAV 507
            .|:|.||.::|..|.|||..||.|.|:|||||||||||||.||:.|.|.|::.:|..::.  :..
Human   432 TVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHT 496

  Fly   508 DRREDLTLLGELILRPKDGLRVKITP 533
            :.|..|    |||:|.:.||.:::.|
Human   497 EPRRKL----ELIMRAEGGLWLRVEP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	167/495 (34%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	163/485 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154695
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.797146	Normalized mean entropy	S2580
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.600