DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp3a57

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001093650.1	Gene:	Cyp3a57 / 622127	MGIID:	3646373	Length:	503	Species:	Mus musculus

Alignment Length:	538	Identity:	146/538 - (27%)
Similarity:	255/538 - (47%)	Gaps:	65/538 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QVISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIE----MNVDHDELF 81
            ::|...|..|..||.:.|:|..:|......|.|.: .||||..:|..||.|.    |....|:.:
Mouse     2 ELIPNLSIQTWVLLVTSLVFFYIYGTYSHGLFKKL-GIPGPKPLPLFGNIINYLDGMWKFDDDCY 65

  Fly    82 NRVIGMQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQ---KFVNKSHDYDYLHP-----W 138
            .:   ..|:||       .::|..|.:.:.:||.::.:|..:   .|.|:       .|     :
Mouse    66 KK---YGKIWG-------FYEGPQPILAIMDPEIIKIVLVKECYSVFTNR-------RPFGPVGF 113

  Fly   139 LGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKL-AVEVGSEAFNLFPYVTL 202
            |.:.:..|.|.:|...|.:|:|.|....|.:...:..:...:|.|.| ..|...|..|:......
Mouse   114 LKKSITISEDEEWKRLRTLLSPTFTSSKLKEMFPIMRQYGDILVRNLRREEEKEEPINMKDIFGA 178

  Fly   203 CTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFS-LTAEYKLHQSYI 266
            .::|::..|:.|..|.:.:|.:..:|:.   |..|::.:....:|.|..:|. ||..|::....|
Mouse   179 YSMDVITGTSCGVNIDSLNNPQDPFVQK---IKKILKFKFFDPFLLSVVLFPFLTPIYEMLNLSI 240

  Fly   267 ---NTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDA-SKEG--- 324
               .:::.|...|.:.:|..|                   |..:|.|:.||.|:::. :.:|
Mouse   241 FPRQSMNFFKKFVKKMKKDRL-------------------DYNQKNRVDFLQLMMNTQNSKGQES 286

  Fly   325 -TVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKN 388
             ..||:.::..:...|:|.|:|.||.:||:.::.|..||:.|:::.:|:|...  ..:.|.|...
Mouse   287 LKALSDLEMAAQTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQDEIDRAL--PNKAPVTYDA 349

  Fly   389 LMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQF 453
            ||||.||:..:.:||||:|.|..:.|...:||.|.|..:|.||..:|..|.|||:|..:|:||.|
Mouse   350 LMDMEYLDMVVNESLRLYPVVSRIDRFSKKDVEIHGVFIPKGTIVMIPIYPLHRDPEYWPEPEDF 414

  Fly   454 NPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRRE-DLTLLG 517
            .|:.|..||.....|:.|:||..|||||||.:||::..|..::.||:.:.::..:..: .:.:..
Mouse   415 CPERFSKENKGNIDPYIYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEETQIPVKISR 479

  Fly   518 ELILRPKDGLRVKITPRD 535
            :.|.||:..:.:|...||
Mouse   480 QPIFRPEKPIILKFVSRD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	132/494 (27%)
Cyp3a57	NP_001093650.1	p450	39..493	CDD:278495	132/494 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820