DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and CYP4F11

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001122404.1	Gene:	CYP4F11 / 57834	HGNCID:	13265	Length:	524	Species:	Homo sapiens

Alignment Length:	450	Identity:	166/450 - (36%)
Similarity:	259/450 - (57%)	Gaps:	35/450 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 RVWQG-TAPRVLLFEPETVEPILNSQKFVNKSH--DYDYLHPWLGEGLLTSTDRKWHSRRKILTP 160
            ::|.| |.|.::|..|:.:.||.::...|....  .|.:|.||||:|||.|...||...|::|||
Human    89 KLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTP 153

  Fly   161 AFHFKILDDFIDVFNEQSAVLA---RKLAVEVGSEAFNLFPYVTLCTLDIVCETAMGRRIYA-QS 221
            ||||.||..::.:||:...::.   ::||.| ||...::|.:::|.|||     ::.:.::: :|
Human   154 AFHFNILKPYMKIFNKSVNIMHDKWQRLASE-GSARLDMFEHISLMTLD-----SLQKCVFSFES 212

  Fly   222 NSE---SEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAE 283
            |.:   |||:.|:..:.:.|:.|..:|.|.:||::.||.:.:..:...:.:|.|::.||:||:..
Human   213 NCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCT 277

  Fly   284 LAILQENNNNNNNNAPDAYDDVGKKKRLAFLD-LLIDASKEGTVLSNEDIREEVDTFMFEGHDTT 347
            |.         .....|...:..|.|.|.|:| ||:...::|..||:||||.|.|||||||||||
Human   278 LP---------TQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTT 333

  Fly   348 SAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMM 412
            ::.:||.|:.|..||||||:..:|:..:..|.:.......:|..:.:|..|||:||||.|.||::
Human   334 ASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVI 398

  Fly   413 ARMVGED-VNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSA 476
            :|...:| |...|:::|.|...:|....:|.||.|:|.||.::|..|..||...|.|.|:|||||
Human   399 SRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSA 463

  Fly   477 GPRNCIGQKFAILEEKAVISTVLRKYKI---EAVDRREDLTLLGELILRPKDGLRVKITP 533
            ||||||||.||:.|.|.|::..|..::|   ....||:.     |||||.:.||.:::.|
Human   464 GPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKP-----ELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	165/446 (37%)
CYP4F11	NP_001122404.1	p450	52..506	CDD:365848	160/436 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154680
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650