DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	519	Identity:	248/519 - (47%)
Similarity:	352/519 - (67%)	Gaps:	32/519 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VFLLG----SILIFLV---VYNKRRSRLVKYIE--KIPGPA-AMPFLGNAIEMNVDHDELFNRVI 85
            :::||    ::|:.|:   .||..::.:.|:.|  .|||.| |.|.:|||::...:..:.||::|
Zfish     7 LYILGILFTAVLLLLLASTAYNPLKNYIGKWNEMRPIPGMAGAYPIIGNALQFKTNAGDFFNQII 71

  Fly    86 GMQKLWGT----RIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWLGEGLLTS 146
            .     ||    .:.:.:||.|..|.::|:..|.:|.:|::.:.::||:.|.:||||||.|||||
Zfish    72 E-----GTNENRHLPLAKVWVGPVPFLILYHAENIEVVLSNSRHLDKSYSYRFLHPWLGTGLLTS 131

  Fly   147 TDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEAFNLFPYVTLCTLDIVCET 211
            |..||.:|||:|||.|||.||.||::|.|||:.:|.:|:......|.||.|.::|||.|||:|||
Zfish   132 TGEKWRNRRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQKLEDGEPFNCFNFITLCALDIICET 196

  Fly   212 AMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMV 276
            |||::||||||::||||::||.:..|:..||...||..|:|::...|.|.|...:..||.|:..|
Zfish   197 AMGKKIYAQSNADSEYVQSVYKMSDIITKRQRAPWLWPDWIYNKLKEGKEHAKRLKILHSFTANV 261

  Fly   277 IRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKE-GTVLSNEDIREEVDTFM 340
            |||| ||..          ::.||:..|.|::||.||||:|:..:.| |..||:|||:|||||||
Zfish   262 IRER-AEFM----------SSEPDSDSDQGERKRQAFLDMLLKTTYENGQKLSHEDIQEEVDTFM 315

  Fly   341 FEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRL 405
            |||||||:|:::|.|.|:|.|||.|:.|..||..:|| ..|....:::|..:|||||.||:|||:
Zfish   316 FEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFG-SSERHVGVEDLKKLRYLECVIKESLRI 379

  Fly   406 FPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFA 470
            |||||:.||.:.|..:|.|..||.|..|:|:.|||||:||.||:||:|.|:.|:|||..||||:|
Zfish   380 FPSVPLFARSICEACHINGFKVPKGVNAVIIPYALHRDPRYFPEPEEFQPERFMPENSKGRHPYA 444

  Fly   471 YIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVKITPR 534
            ||||||||||||||:||::|||.|::|:||.:.:||...||:|..||||||||:.|:.:|:..|
Zfish   445 YIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVEACQSREELRPLGELILRPEKGIWIKLQRR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	237/477 (50%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	237/477 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589824
Domainoid	1	1.000	473	1.000	Domainoid score	I420
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1418
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		otm26051
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4308
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.930