DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	527	Identity:	244/527 - (46%)
Similarity:	340/527 - (64%)	Gaps:	26/527 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLSKVGQVISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPA---AMPFLGNAIEMNVD 76
            :::.||....|:...:|.:   |....:.|...:|.|.|:.|..|.|.   ..||:|||::...:
Zfish     1 MVAFVGVYTYGFVAASVCV---ICFAYITYQLLKSYLHKWKELKPIPGIGNTFPFIGNALQFKSN 62

  Fly    77 HDELFNRVIGMQKLWGTRI---GINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPW 138
            .| .|.:::|    :.|..   .:.::|.|..|.::||..||||.:||:...::|::.|.:||||
Zfish    63 GD-FFLQLVG----YTTEFQNSPLLKIWIGPIPFLILFHAETVETVLNNPVHIDKAYAYQFLHPW 122

  Fly   139 LGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEAFNLFPYVTLC 203
            ||.||||||..||..|||:|||.|||.||.:|::|.|||:.||..||..:.|...||.|.::|||
Zfish   123 LGTGLLTSTGDKWRRRRKMLTPTFHFSILTEFLEVMNEQAEVLIEKLEKQAGKGPFNCFSHITLC 187

  Fly   204 TLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINT 268
            .|||:||||||:|||||||.:||||:.||.:..|:..||...|...||:::...|.:.|...:..
Zfish   188 ALDIICETAMGKRIYAQSNYDSEYVRTVYRMSDIITRRQRMPWYWPDFVYNYVGEGREHNRSLKI 252

  Fly   269 LHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKE-GTVLSNEDI 332
            ||.|:..||.||...|:.::.          |:..|.|.:||.||||:|:....| |.:|:::||
Zfish   253 LHSFTESVINERAEYLSYVES----------DSESDQGMRKRRAFLDMLLKTKDEDGKMLTHKDI 307

  Fly   333 REEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLEC 397
            :||||||||||||||:||::|.:.|||.|||.|.:..:||..:|| :.|.|...::|..:|||||
Zfish   308 QEEVDTFMFEGHDTTAAAMNWAIHLLGSHPEVQRKAQQELFEVFG-ESERPVNTEDLKKLRYLEC 371

  Fly   398 CIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPEN 462
            .||:|||||||||..||.:.:|..|.|..||.||..:::||||||:||.||.||:|.|:.|||||
Zfish   372 VIKESLRLFPSVPFFARTICDDTQINGFKVPKGTNIVVITYALHRDPRFFPDPEEFRPERFLPEN 436

  Fly   463 CAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGL 527
            |.||||:||||||||.||||||:|||:|||.:::.:||.:.|.|..:||:|..||||:|||:.|:
Zfish   437 CVGRHPYAYIPFSAGLRNCIGQRFAIMEEKVILAYILRYFNIVACQKREELRPLGELVLRPEQGI 501

  Fly   528 RVKITPR 534
            .:.:..|
Zfish   502 WITLERR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	233/478 (49%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	231/472 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589821
Domainoid	1	1.000	473	1.000	Domainoid score	I420
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1418
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		otm26051
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.800