DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	538	Identity:	130/538 - (24%)
Similarity:	240/538 - (44%)	Gaps:	77/538 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ITVFLLGSILIFLVVYNKRRSRLVKYIE-KIPGPAAMPFLGNAIE-----MNVDHDELFNRVIGM 87
            :|..|:..::..|.:|.....|.  :|: .||||...||:|..:.     .|.|.:  ..:..|
Zfish     9 VTWTLVVLVITLLFIYGVWPHRF--FIKLGIPGPRPWPFVGTLLSYAKGLCNFDME--CAKKYG- 68

  Fly    88 QKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQ---KFVNKSHDYDYLHPWLGEGLLTSTDR 149
             |:||       ::.|..|.:::.:.|.::.:|..:   .|:|:......|.....:|::...|.
Zfish    69 -KVWG-------IYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIMVKDE 125

  Fly   150 KWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEAFNLFPYVTLCTLDIVCETAMG 214
            :|...|..|:|.|....|.:...:....:....:.:..:...:...:...|...:||::..::..
Zfish   126 RWKRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKKDPEQPVKIKEVVAPYSLDVITSSSFS 190

  Fly   215 RRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRE 279
            ..|.:.:|.|..:|..|                 ..||     ::.:....:..:..|.::.|..
Zfish   191 VDIDSINNPEDPFVINV-----------------KKFI-----QFNMFNPLLLLILLFPSLAIPL 233

  Fly   280 RKAELAILQENNNNNNNNAPDAY--------DDVGKKK--RLAFLDLLI------------DASK 322
            :|..:.:.       :.:|.|.:        ||..|:.  |:.||.|::            |.|:
Zfish   234 KKMGVTLF-------SKSAMDFFYSVLKKIKDDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSE 291

  Fly   323 E-GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATM 386
            : ...|::.:|..:...|:..|::|||..:::.|:.|..:|:..|::|||:|..|..|  ||.|.
Zfish   292 QPAKGLTDHEILSQSLVFILGGYETTSTTLTFLLYNLATNPDCLEKLVEEIDKNFPLD--TPITY 354

  Fly   387 KNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPE 451
            ..||.|.|||..|.:|:||.|:.|.:.|...:.|.|.|..:|.||...|.||.|..:|.::..|.
Zfish   355 DALMRMDYLEMAINESMRLLPTAPRLERSAKKTVVINGLTIPEGTLVGIPTYVLSHDPDIWESPG 419

  Fly   452 QFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLL 516
            :|.|:.|.|||.:....:|:|||..|||||||.::|::..|..:..:|:.:.:|.. :...:.|.
Zfish   420 EFRPERFSPENKSEFLQYAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETC-KETQIPLE 483

  Fly   517 GELILRPKDGLRVKITPR 534
            ..:..:||..:.:|:.||
Zfish   484 MNVTFQPKVPITLKLIPR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	120/502 (24%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	118/489 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900