DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001178915.1	Gene:	Cyp4f17 / 500801	RGDID:	1561655	Length:	524	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	184/548 - (33%)
Similarity:	287/548 - (52%)	Gaps:	78/548 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GYSPITV------------FLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDH 77
            |..|:||            .||..||.::..:.....||    ...|.|.:..:....:.:..::
  Rat    10 GRGPVTVSPWQLLLVVGTSLLLARILAWISAFYDNYCRL----RCFPQPPSRHWFWGHLNLVKNN 70

  Fly    78 DELFNRVIGMQKL-------------WGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFV--N 127
            :|      |:|.|             |   |||      ..|.:.|..|:.:.|||.:...|  .
  Rat    71 EE------GLQLLAEMSHQFQDIHLCW---IGI------FYPILRLIHPKFIGPILQAPAAVAPK 120

  Fly   128 KSHDYDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARK---LAVEV 189
            :...|.:|.||||:|||.|...||..:|::|||||||.||..::..||:...::..|   |..:
  Rat   121 EMIFYGFLKPWLGDGLLVSAGEKWSRQRRLLTPAFHFDILKPYVKNFNKSVNIMHAKWQRLTAK- 184

  Fly   190 GSEAFNLFPYVTLCTLDIVCETAMGRRIYA-QSN---SESEYVKAVYGIGSIVQSRQAKIWLQSD 250
            ||...::|.:::|.|||     ::.:.::: .||   |.|||:.|:..:.|::..|..:.:|..|
  Rat   185 GSARLDMFEHISLMTLD-----SLQKCVFSFDSNCQESPSEYIAAIQELSSLIVKRHHQPFLYMD 244

  Fly   251 FIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLD 315
            |::.|||:.:..:...:.:|.|::.|||||:..|         ::.:..:......|.|.|.|:|
  Rat   245 FLYYLTADGRRFRKACDLVHNFTDAVIRERRRTL---------SSQSVDEFLKSKTKSKTLDFID 300

  Fly   316 LLIDASKE-GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDD 379
            :|:.|..| |..||:||||.|.|||||.|||||::|:||.|:.|..|||:|||..:|:..:..|.
  Rat   301 VLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEHQERCRQEVRELLRDR 365

  Fly   380 KETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRN 443
            :.......:|..:.:|..|||:||||.|.|.:::|...:||.: .|:::|.|...||..:.:|.|
  Rat   366 EPEEIEWDDLTQLPFLTMCIKESLRLHPPVTVISRCCTQDVVLPDGRVIPKGNDCIISIFGVHHN 430

  Fly   444 PRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVD 508
            |.|:|.||.::|..|..||...|.|.|:|||||||||||||.||:.|.|..::..|.::::...|
  Rat   431 PSVWPDPEVYDPFRFDSENPQKRSPLAFIPFSAGPRNCIGQTFAMNEMKVAVALTLLRFRLLPDD 495

  Fly   509 ---RREDLTLLGELILRPKDGLRVKITP 533
               ||:.     |||||.:.||.:::.|
  Rat   496 KEPRRKP-----ELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	173/498 (35%)
Cyp4f17	NP_001178915.1	p450	52..514	CDD:278495	173/496 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348429
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650