DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp4p1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	176/524 - (33%)
Similarity:	282/524 - (53%)	Gaps:	38/524 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VFLLGSILIFLVVYNK---------RRSRL-----VKYIEKIPGPAAMPFLGNAIEM-NVDHDEL 80
            :..|.::|.:|...||         :|.||     |:.|  .|........||.::: ..||..:
  Fly     7 ILALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEII--APIAKGKTIFGNTLDLYGRDHAGV 69

  Fly    81 FNRVIGMQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWLGEGLLT 145
            ||......|..||.. |..|:......::  :.::.|.:||....:.|...|::|||:|..||||
  Fly    70 FNYSRERAKEMGTSY-IEYVFGKAIYNII--DADSAENVLNHPNLITKGLVYNFLHPFLRTGLLT 131

  Fly   146 STDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSE---AFNLFPYVTLCTLDI 207
            ||.:|||:|||:|||.|||.||:.|.::|..:|    :|..::...:   ...|...:...||:.
  Fly   132 STGKKWHARRKMLTPTFHFNILNQFQEIFKTES----QKFLLQFEGQDEVTITLHDVIPRFTLNS 192

  Fly   208 VCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGF 272
            :||||||.::...:.....|.:....|......|.:...|..|.:|.:.|. |...|.::.:|.|
  Fly   193 ICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKLFEMFAA-KDFASALDVVHRF 256

  Fly   273 SNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVD 337
            |:.:|.:|:   .:|::..:.:::.|.|  |....|||.|.||.||.|.|:| ::.:..|.||||
  Fly   257 SSEIIAKRR---DLLKDELDKSSSTADD--DGFVSKKRFAMLDTLIYAEKDG-LIDHIGICEEVD 315

  Fly   338 TFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDS 402
            |.||||:||||..:.:.|..:..:|:.||...:|:.....||... ..:..|..::|||..:|::
  Fly   316 TLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDDDLSN-LDVGQLNKLKYLEYFMKET 379

  Fly   403 LRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGR 466
            .|||||||:|.|...::..: .|.|:|.|.|..|..:.:|||.:.:..||:|.|:.|||||...|
  Fly   380 TRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHRNAKYWDSPEEFRPERFLPENVQDR 444

  Fly   467 HPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKI-EAVDRREDLTLLGELILRPKDGLRVK 530
            |.:||:|||||.|||||:|:|:.|.|.::..:|:::|: :|:|.::.:...| :.||.:|.:|||
  Fly   445 HTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVLKAIDPQKIVFHTG-ITLRTQDKIRVK 508

  Fly   531 ITPR 534
            :..|
  Fly   509 LVRR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	164/477 (34%)
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	163/470 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460480
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000