DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp313a3

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	143/511 - (27%)
Similarity:	237/511 - (46%)	Gaps:	43/511 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVIGMQKLWGTRIGI 97
            ||...:.|.:.:...|.||.....|||||..:|.||.|.|..:.:....:.......::|:..
  Fly     7 LLAVGVCFWIYFLWSRRRLYMMHFKIPGPMGLPILGIAFEYLITYKRKMSIRTKYMDIYGSTC-- 69

  Fly    98 NRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDY-LHPWLGEGLLTSTDRKWHSRRKILTPA 161
             .||.|..|.|:..:|:..|.|..|.:.:|:|..:.. ::...|:|||:....||..|||.|.||
  Fly    70 -LVWVGPTPFVITRDPKIAEEIFLSPECLNRSSIFSKPVNSCTGDGLLSLEASKWVDRRKNLNPA 133

  Fly   162 FHFKILDDFIDVFNEQSAVLARKLAVEVGSEAFNLFPYVTLCTLDIVCETAMGRRIYAQSNSESE 226
            |...:|..|:.:||.::..|...|...||.....:...:...:..|..:|.:|..:...::.:::
  Fly   134 FKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGEKKVRDDIVRWSFRIATQTTVGTDVKKDASFKND 198

  Fly   227 YVKAVYGIGSIVQSRQA--KIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQE 289
                     |:::|.:.  || :..:.:...|     |....:||.||        :.:.|:.:.
  Fly   199 ---------SVLKSYETFMKI-IVMNVLLPFT-----HNKIFSTLGGF--------ETQKALAKS 240

  Fly   290 NNNNNNNNAPD----AYDDVGKKKRL-AFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSA 349
            |.|.......|    ...:.|.:..: :.::..|:..:.|. :|.|:::.|..:|:....:||..
  Fly   241 NVNKMIGTIVDKKLMTKPESGSQPEITSVINKAIELHRNGE-MSREEVQSECCSFVVAAFETTGD 304

  Fly   350 AISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMAR 414
            .:...|.||...||:|:.|.:||..:|....:...|..:|..|.:||..:.::|||.||||...|
  Fly   305 TVYHALILLAMFPEHQDTVYQELKELFPVAGDFEVTYDDLQRMVFLERVVNETLRLIPSVPFTPR 369

  Fly   415 MVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVF-PKPEQFNPDNFLPENCAGRHPFAYIPFSAG 477
            ....|..: .|.::|.|....|..:|.|||...: ..|..||||:|||:|...|||:||||||.|
  Fly   370 ETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFNPDHFLPDNVRDRHPYAYIPFSKG 434

  Fly   478 PRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVKITP 533
            .|||||.|:.::..|..:|.:||..|:....|.|||..:..:      |:.:..:|
  Fly   435 RRNCIGWKYGLMSSKLALSKILRNCKVSTSFRYEDLEFVDNI------GMELAQSP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	134/481 (28%)
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	129/456 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.860