DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and cyp20a1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_998497.2	Gene:	cyp20a1 / 406641	ZFINID:	ZDB-GENE-040426-2646	Length:	463	Species:	Danio rerio

Alignment Length:	531	Identity:	107/531 - (20%)
Similarity:	208/531 - (39%)	Gaps:	106/531 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNR------VIGMQK 89
            :.|:|::| :|...::|.|             .:|.|....|.:.:..::.|:      ::|:..
Zfish    13 IILIGAVL-YLYPSSRRAS-------------GVPGLNPTEEKDGNLQDIVNKGSLHEFLVGLHD 63

  Fly    90 LWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWL----------GEGLL 144
            .:|:   :...|.|..|.|      ::..:...::.:|.:...|.....|          |.||.
Zfish    64 EFGS---VASFWFGARPVV------SLGAVNQLRQHINPNWTTDSFETMLKSLLGYQSGSGVGLT 119

  Fly   145 TSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEAFNLFPYVTLCTLDIVC 209
            .|..||     |:...|.: |.|::...:..:|...|..|.|....|:...|..::....:..|.
Zfish   120 ESMMRK-----KVYEGAIN-KTLENNFPLLLQQVEELVDKWASYPKSQHMPLCAHLLGLAMKAVT 178

  Fly   210 ETAMGRR-------IYAQSNSE---SEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQS 264
            :.|||.|       |..:.|.|   ||..|. |..||:.:|...|            |.|   :|
Zfish   179 QLAMGSRFRDDAEVIRFRKNHEAIWSEIGKG-YLDGSLEKSSSRK------------AHY---ES 227

  Fly   265 YINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGTVLSN 329
            .:..:......|.::|..:                       ...:.:|::.|:.|:     |:.
Zfish   228 ALAEMESVLKSVAKQRPGQ-----------------------GSSQSSFVNYLLQAN-----LTE 264

  Fly   330 EDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRY 394
            ..:.|:...|...|...|:....|.:..|......|:|:..||..:.||:   |.:::.:..:||
Zfish   265 RQVMEDGMVFTLAGCVITANLCIWAVHFLSVSEAVQDRLYHELVEVLGDE---PVSLEKIPQLRY 326

  Fly   395 LECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFL 459
            .:..:.:::|.....|:.||:...:..:...::|..|..|.....:.::...:..|.:||||.|.
Zfish   327 CQQVLNETVRTAKLTPVAARLQEVEGKVDQHVIPKETLVIYALGVVLQDADTWSLPYRFNPDRFA 391

  Fly   460 PENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPK 524
            .|:.  ...|:.:.|| |.:.|...:||......::||::|:.::..|| .:.:....||:..||
Zfish   392 EESV--MKSFSLLGFS-GSQACPELRFAYTVATVLLSTLVRRLRMHRVD-GQVVEARYELVTTPK 452

  Fly   525 DGLRVKITPRD 535
            |...:.::.|:
Zfish   453 DDTWITVSKRN 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	100/497 (20%)
cyp20a1	NP_998497.2	p450	43..452	CDD:299894	94/474 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910