Protein Alignment Cyp4c3 and CYP4F3

DIOPT Version :9

• Sequence 1: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 183/540 - (33%)
• Similarity: 278/540 - (51%)
• Gaps: 51/540 - (9%)

  Fly    10 MAES--ILLSKVGQVISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLG---- 68
            ||.|  :||..||         ..:||..||.:...:.....||..:.:.   |....|||
Human    14 MAASPWLLLLLVG---------ASWLLARILAWTYTFYDNCCRLRCFPQP---PKRNWFLGHLGL 66

  Fly    69 -NAIEMNVDHDELFNRVIGMQKLW--GTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSH 130
             ::.|..:.:.:......|....|  |....|.|::..|..:.:||.|..:.|  ..:.|
Human    67 IHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVP--KDKVF----- 124

  Fly   131 DYDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARK--LAVEVGSEA 193
             |.:|.||||:|||.|...||...|::|||||||.||..::.:|||...::..|  |....||..
Human   125 -YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSAR 188

  Fly   194 FNLFPYVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAE 258
            .::|.:::|.|||.:.:.......:.| ...|||:.|:..:.::|..|..:|.|..||::.||.:
Human   189 LDMFEHISLMTLDSLQKCVFSFDSHCQ-EKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPD 252

  Fly   259 YKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLD-LLIDASK 322
            .:..:.....:|.|::.||:||:..|.         :....|......|.|.|.|:| ||:...:
Human   253 GQRFRRACRLVHDFTDAVIQERRRTLP---------SQGVDDFLQAKAKSKTLDFIDVLLLSKDE 308

  Fly   323 EGTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMK 387
            :|..||:||||.|.|||||||||||::.:||.|:.|..|||||||..:|:..:..|.:.......
Human   309 DGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWD 373

  Fly   388 NLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVFPKPE 451
            :|..:.:|..|||:||||.|.||.::|...:|:.: .|:::|.|...:|..:..|.||.|:|.||
Human   374 DLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPE 438

  Fly   452 QFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKI---EAVDRREDL 513
            .::|..|.|:|...|.|.|:|||||||||||||.||:.|.|.|:...|.::::   ....||:.
Human   439 VYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKP- 502

  Fly   514 TLLGELILRPKDGLRVKITP 533
                ||:||.:.||.:::.|
Human   503 ----ELVLRAEGGLWLRVEP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	169/485 (35%)
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	169/488 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154686
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650