DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp312a1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	167/494 - (33%)
Similarity:	276/494 - (55%)	Gaps:	32/494 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVIGMQKLWGTRIGI 97
            ||.::.::|:...:|:||:.:...|.|.|.|:||:|        |..:..:::|...|......|
  Fly     9 LLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIG--------HLHILAKLVGPHPLRRATEMI 65

  Fly    98 N--------RVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWLGEGLLTSTDRKWHSR 154
            |        ::|.||...::...|:.::.:.::|:.:.|::||.....||.|||.||...||..|
  Fly    66 NEHLHDHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEKWSHR 130

  Fly   155 RKILTPAFHFKILDDFIDVFNEQSAVLARKLA--VEVGSEAFNLFPYVTLCTLDIVCETAMGRRI 217
            |||:.|||::.::..|:.||.:||.:|...:|  .|.|.: .:....::..|||.:||||:|..:
  Fly   131 RKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQ-IDFLQLISCFTLDTICETALGVSV 194

  Fly   218 YAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKA 282
            .:||:::|||:.||..|..|:..|...|:.::.|||..|:.||..|..|.|||||:..:|::|..
  Fly   195 GSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTEGIIQKRID 259

  Fly   283 ELAILQENNNNNNNNAPDAYDDVGKKKRLAFLD-LLIDASKEGTVLSNEDIREEVDTFMFEGHDT 346
            |   :.::..|.|..:.||..| |.|:.|.||| ||:....:|..|:.:||||||||.:|.|.|.
  Fly   260 E---INQDAENRNYQSSDAELD-GVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTIIFGGFDL 320

  Fly   347 TSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPM 411
            |:..:::.::.:..|||:|:|..||:.|:.|.||..|.:::.:..:.:||.|||::||::||.|:
  Fly   321 TATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMYPSGPL 385

  Fly   412 MARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHP----FAYI 472
            .||....:..|....:|.|:..||....:.|....||.|..|.||.:    ..|..|    ..:|
  Fly   386 TARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRW----AIGAEPKIEATTFI 446

  Fly   473 PFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRRE 511
            ||.||.|:|:||::|::..|.|::.:||.:..|.:..|:
  Fly   447 PFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQ 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	160/468 (34%)
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	160/468 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460448
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	8.890