DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and cyp46a1.4

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_005160404.1	Gene:	cyp46a1.4 / 393451	ZFINID:	ZDB-GENE-040426-1224	Length:	501	Species:	Danio rerio

Alignment Length:	534	Identity:	141/534 - (26%)
Similarity:	238/534 - (44%)	Gaps:	84/534 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ITVFLLGSILIFLVVYNKRRSRLVKYI----EKIPGPAAMPFL-GNAIEM--------NVDHDEL 80
            |..:||.::....:.|    ...:.|:    :.||||....|| |::..:        ::.|| |
Zfish     9 IIFYLLSAVFTAFLAY----CLYIHYVHQKYDHIPGPPRDNFLFGHSPSLTKSMYADDSLIHD-L 68

  Fly    81 FNRVIGMQKLWGTRIG-INRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYL-----HPWL 139
            |.:       |..:.| :.|:.......:::..||..:.||.|.|:......|..|     ..:|
Zfish    69 FLQ-------WAEKYGPVYRINSLHYIAIVVHCPEATKTILMSPKYTKDPFVYRRLFNLFGKRFL 126

  Fly   140 GEGLLTSTDRK-WHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEAFN------LF 197
            |.||:|:.|.. |:.:|:|:.|||....|...|..|:|.|..|..||     .|..|      :.
Zfish   127 GYGLITAVDHDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKL-----EEMANNKTPAVMH 186

  Fly   198 PYVTLCTLDIVCETAMGRRIYAQSNSESEYVKAV----YGIGSIVQSRQAKIWLQSDFIFSLTAE 258
            ..|...|||::|:.|.|..:...:..:|.:..||    .|:         .:.|:..|.......
Zfish   187 DLVNCVTLDVICKVAFGVDLNFLAQKDSPFQNAVELCLNGM---------TVDLRDPFFRLFPKN 242

  Fly   259 YKL-HQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASK 322
            :|| ||             ||:....|....|....|...|....:||.|.    .|..::.:::
Zfish   243 WKLIHQ-------------IRDAAELLRKTGEKWIQNRKTAVKNGEDVPKD----ILTQILKSAE 290

  Fly   323 EGTVLSNEDIREEVD---TFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPA 384
            |..|.:.:|:.:.:|   ||...|.:||:..:|:.:..||.:||..:|...|:|.:.|..:|  .
Zfish   291 EENVNNTDDLEQMLDNFVTFFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEVLGTKRE--I 353

  Fly   385 TMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPK 449
            :.::|....||...:|::|||:|:.|...|.:.||:.|.|..:|.|...:..:|...|..:.|..
Zfish   354 SNEDLGKFTYLSQVLKETLRLYPTAPGTNRWLHEDMVINGIKIPGGCSVMFSSYVSQRLEKFFKD 418

  Fly   450 PEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRRE-DL 513
            |.:|:|:.|  :..|.:..:.|.||:.|||.|:||.|:.:|.|.|::.:|::::...|..:. |:
Zfish   419 PLKFDPERF--DVNAPKPYYCYFPFALGPRTCLGQVFSQMEAKVVLAKLLQRFEFSLVPGQSFDI 481

  Fly   514 TLLGELILRPKDGL 527
            ...|  .||||.|:
Zfish   482 KDTG--TLRPKSGV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	135/500 (27%)
cyp46a1.4	XP_005160404.1	p450	39..495	CDD:278495	135/500 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810