DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	529	Identity:	180/529 - (34%)
Similarity:	281/529 - (53%)	Gaps:	42/529 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VISGYSPIT---------VFL--LGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNV 75
            ::.|.||..         :||  |.:::..|:|    |.:.||.:|:.|||.|....|:..|...
Zfish     2 LLYGISPFVLSVNHVFALIFLACLLTVVKLLIV----RRKGVKTMERFPGPPAHWLFGHVKEFRQ 62

  Fly    76 D-HDELFNRVIGMQKLWGTRIGINRVWQGTAPRVL-LFEPETVEPILNSQKFVNKSHDYDYLHPW 138
            | ||  ..:::...:|:.....:   |.|.:..|| :..|..|:.||.:.: ....:.|.:..||
Zfish    63 DGHD--LEKIVKWMELYQFAFPL---WFGPSLAVLNIHHPSYVKTILTTTE-PKDDYAYKFFIPW 121

  Fly   139 LGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGS-EAFNLFPYVTL 202
            ||:|||.||.:||...|::|||.||:.:|..::.:.::.:.|:..|..|...| |:|.||.:|:|
Zfish   122 LGDGLLVSTGQKWFRHRRLLTPGFHYDVLKPYVKLISDSTKVMLDKWEVHSRSEESFELFKHVSL 186

  Fly   203 CTLDIVCETAMGRRIYAQSNS-ESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYI 266
            .|||.:.:.|.......|::| .:.|::||:.:..:|..|.......|..||.|:......:...
Zfish   187 MTLDSIMKCAFSCNSNCQTDSGTNPYIQAVFDLCHLVNLRFRVFPYHSKAIFHLSPHGYRFRKAA 251

  Fly   267 NTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGTV-LSNE 330
            :..|..:..|||:||..|.:.:|.....|            ::.|.|||:|:.|..|... ||:|
Zfish   252 SIAHNHTAEVIRKRKEVLKMEEEQGIVKN------------RRYLDFLDILLSARDEHQQGLSDE 304

  Fly   331 DIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYL 395
            |||.|||||||||||||::.|||..:.|.|:||:||:..:|:.... |.|.| ...::|..:.|.
Zfish   305 DIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCRQEIQQAL-DGKAT-LEWEDLNKIPYT 367

  Fly   396 ECCIKDSLRLFPSVPMMARMVGEDVN-IGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFL 459
            ..|||:||||.|.||.::|.:.:.:. ..|:.||.|....:..|.:|.|..|:..|.:|:|..||
Zfish   368 TMCIKESLRLHPPVPGISRKLTKPLTFFDGRTVPEGCTIGVSIYGIHMNSTVWENPYKFDPLRFL 432

  Fly   460 PENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPK 524
            |||.|.|.|.|::||||||||||||.||:.|.|..::..|::|.: ..|......::.:::||..
Zfish   433 PENVANRSPHAFVPFSAGPRNCIGQNFAMNEMKVAVALTLKRYYL-IKDPDHTPKMIPQVVLRSL 496

  Fly   525 DGLRVKITP 533
            :|:.:||.|
Zfish   497 NGIHIKIKP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	165/477 (35%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	165/475 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720