DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	123/548 - (22%)
Similarity:	235/548 - (42%)	Gaps:	99/548 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ITVFLLGSILIFL---VVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVIGMQKL 90
            :.|.||..:..::   :.|.|||.        ||..|.....||                 |::|
  Fly    10 VAVALLAILTYYIHRKLTYFKRRG--------IPFVAPHLIRGN-----------------MEEL 49

  Fly    91 WGTRIGINRVWQG------------------TAPRVLLFEPETVEPIL--NSQKFVNKSHDYDYL 135
            ..|: .|:.::|.                  .:|...:.:.|..:.||  :...|.||...|:..
  Fly    50 QKTK-NIHEIFQDHYNKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEK 113

  Fly   136 HPWLGEGLLTSTDRKWHSRRKILTPAF---HFKIL-DDFIDVFNEQSAVLARKLAVEVGSEAFNL 196
            ...:...|......:|...|..|:..|   ..|:: ...:.|.||...|:..|:......|..:|
  Fly   114 DDPISAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDL 178

  Fly   197 FPYVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFS---LTAE 258
               |...|:|::...|.|.:..:..:.::|::  .:|..|:|..|...  |.:.|:.|   |..:
  Fly   179 ---VARFTVDVIGTCAFGIQCNSLRDEKAEFL--YFGKRSLVDKRHGT--LLNGFMRSYPKLARK 236

  Fly   259 YKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDA--S 321
            ..:.::..:....:|.:|     .|...::|..:...|:               |:|:||:.  .
  Fly   237 LGMVRTAPHIQEFYSRIV-----TETVAVREKEHIKRND---------------FMDMLIELKNQ 281

  Fly   322 KEGTV--------LSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGD 378
            ||.|:        |:.|::..:...|...|.:|:|:.:.:.|:.|..:|:.|::|..|::.:. :
  Fly   282 KEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVI-E 345

  Fly   379 DKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGK---IVPAGTQAIIMTYAL 440
            ..:...|.:...|::||...:.::|||:..||.:.||..:...:.|.   ::.||...||.:.|:
  Fly   346 QHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAI 410

  Fly   441 HRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIE 505
            |.:|.::|:|.:|.|:.|.||..|||...|::||..|||||||.:|..::.:..::.::|.:|..
  Fly   411 HHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFS 475

  Fly   506 AVDRREDLTLLG--ELILRPKDGLRVKI 531
            ...:..:..:..  ..:|..|||:.:|:
  Fly   476 TCSKTPNPLVYDPKSFVLGVKDGIYLKV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	114/513 (22%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	112/509 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810