DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and Cyp4p3

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	180/526 - (34%)
Similarity:	284/526 - (53%)	Gaps:	33/526 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ITVFLLGSILIFLV-VYNKRRSRLVK--YIEKI-------PGPAAMPFLGNAIEMN------VDH 77
            :.::|:|:.::.:. :|...|...:.  :.::|       |...|....|:.|..|      .||
  Fly     2 LILWLVGAFIVLIQWIYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLYGKDH 66

  Fly    78 DELFNRVIGMQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWLGEG 142
            ..:|.......|..|....  ....|||...:: :.::.|.:||....:||...||:|||:|..|
  Fly    67 SGVFEHSRDCAKKLGKSYA--EYAMGTAIYNVI-DADSAERVLNDPNLINKGTIYDFLHPFLRTG 128

  Fly   143 LLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEA-FNLFPYVTLCTLD 206
            |||||.:|||:|||:|:|.|||.||:.|.::|..:|.....:.  :...|| .:|...:...||:
  Fly   129 LLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFLEQF--KGNDEAIISLNEVIPRFTLN 191

  Fly   207 IVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHG 271
            .:||||||.::...:.....|.:....|......|.:...|.||.:|.:.|| |.:.|.::.:||
  Fly   192 SICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFAE-KDYASALDVVHG 255

  Fly   272 FSNMVIRERKAELAILQENNNNNNNNAPDAYDDV-GKKKRLAFLDLLIDASKEGTVLSNEDIREE 335
            ||:.:|.:|:.:|    .:..::..|...|.|:: ..|||.|.||.||.|.|:| ::.:..|.||
  Fly   256 FSSEIIAKRRDQL----NDEIDSRGNTQTAEDELFTSKKRFAMLDTLILAEKDG-LIDHIGICEE 315

  Fly   336 VDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIK 400
            |||.||||:||||..:.:.|..:..:||.||:..:|:.:.. ||:.....:..|..::.||..||
  Fly   316 VDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANI-DDELNILNIGQLNKLKNLEYFIK 379

  Fly   401 DSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCA 464
            :::|||||||.|.|....:..: .|.|:|.|:|..:..:.:||||..:..||:|.|:.|||||..
  Fly   380 ETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYWDSPEEFRPERFLPENSQ 444

  Fly   465 GRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKI-EAVDRREDLTLLGELILRPKDGLR 528
            .||.:||||||||.|||||||||:.|.|.::..:|::::| ..:|.:..:...| |.||.|:.:.
  Fly   445 NRHTYAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPEIDPKTIVFQTG-LTLRTKNQIH 508

  Fly   529 VKITPR 534
            ||:..|
  Fly   509 VKLVRR 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	173/481 (36%)
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	168/463 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460479
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm1194
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000