DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp4d21

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	191/521 - (36%)
Similarity:	287/521 - (55%)	Gaps:	36/521 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLG-SILIFLVVY-NKRRSRLVKYIEK--IPGPAAMPFLGNAIEMNVDHDELFNRVIG--MQKLW 91
            ||| ::||..:|: |.|:...|...||  |.||..:|.:||.::......|.|.:..|  ..|..
  Fly     4 LLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRFGDYFNKYG 68

  Fly    92 GTRIGINRVWQGTAPRVLLFEPET--VEPILNSQKFVNKSHDYDYLHPWLGEGLLTSTDRKWHSR 154
            .|    .|:|  .....|::..:.  .|.||:|...:.|:|.|.:|..:||:|||.||..||.||
  Fly    69 KT----FRLW--ILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLSTGNKWTSR 127

  Fly   155 RKILTPAFHFKILDDFIDVFNEQSAVLARKLA-VEVGSEAFNLFPYVTLCTLDIVCETAMGRRIY 218
            ||:|.||||||.|::|:::.:..|.::..||. ...|....:||.:|:|..||:..|||||.::.
  Fly   128 RKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAMGVQVN 192

  Fly   219 AQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAE--YKLHQSYINTLHGFSNMVIRERK 281
            ||:.....|.||:..:..|...|.|.:.::.:::|.|.|.  |:..|..|..:..|::.|||||:
  Fly   193 AQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIMQDFTDKVIRERR 257

  Fly   282 AELAILQENNNNNNNNAPDAY-------DDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVDTF 339
            |.|         ....|...|       ||:|.|.::..||:|:.|:.:...||:.|||||||.|
  Fly   258 AIL---------ERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDVDIREEVDVF 313

  Fly   340 MFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLR 404
            :|.|.|||::.:|..|..:..||:.||.:.|||.|:.|.|.:...|...|::::||:|.||:::|
  Fly   314 IFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMR 378

  Fly   405 LFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLP-ENCAGRHP 468
            |.|.||::.|.:.||:.||...:|..|..::|.|.::|:|..||.|..|.|:.::. :..:...|
  Fly   379 LHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPP 443

  Fly   469 FAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVKITP 533
            .||||||:||:||||||||.|:.||:||.|:|.|  |.:....||......||....|..|.:.|
  Fly   444 LAYIPFSSGPKNCIGQKFANLQMKALISKVIRHY--ELLPLGADLKATYTFILSSSTGNNVGLKP 506

  Fly   534 R 534
            |
  Fly   507 R 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	177/486 (36%)
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	171/463 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460446
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	8.890