Protein Alignment Cyp4c3 and Cyp3a44

DIOPT Version :10

• Sequence 1: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_796354.1
• Gene: Cyp3a44 / 337924
• MGIID: 2449818
• Length: 504
• Species: Mus musculus
• Alignment Length: 548
• Identity: 153/548 - (27%)
• Similarity: 267/548 - (48%)
• Gaps: 86/548 - (15%)

  Fly    22 VISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAI-------EMNVDHDE 79
            :.|..|..|:.||..||:.|..|..|...|.|. :.||||..:||||..:       :.:::..|
Mouse     3 LFSALSLDTLVLLAIILVLLYRYGTRTHGLFKK-QGIPGPKPLPFLGTVLNYYTGIWKFDMECYE 66

  Fly    80 LFNRVIGMQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNS---QKFVNKSHDYDYLHP--WL 139
            .:.      |.||       ::.|..|.:::.:|||::.:|..   ..|.|:..    ..|  .:
Mouse    67 KYG------KTWG-------LFDGQTPLLVITDPETIKNVLVKDCLSVFTNRRE----FGPVGIM 114

  Fly   140 GEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEAFNLFP-----Y 199
            .:.:..|.|.:|...|.:|:|.|....|.:...|..:...:|.:.|.    .||....|     .
Mouse   115 SKAISISKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLR----QEAEKGMPVAMKDV 175

  Fly   200 VTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDF----IFS------ 254
            :...::|::..|:.|..:.:.:|.|..:|:            :||.:|:.||    :||
Mouse   176 LGAYSMDVITSTSFGVNVDSLNNPEDPFVE------------EAKKFLRVDFFDPLLFSVVLFPL 228

  Fly   255 LTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLID 319
            ||..|::    :| :..|.|..|...|..:..:||:..::|           :|.|:.||.|:::
Mouse   229 LTPVYEM----LN-ICMFPNDSIEFFKKFVDRMQESRLDSN-----------QKHRVDFLQLMMN 277

  Fly   320 A---SKE---GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGD 378
            :   ||:   ....||.:|..:...|:..|::|||:.:|:||:.|..||:.|:::..|:|... .
Mouse   278 SHNNSKDKDSHKAFSNMEITVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKAL-P 341

  Fly   379 DKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRN 443
            :|.|| |...:|:|.||:..:.::|||:|.|..:.|:..:||.:.|..:|.|:..:|.:||||.:
Mouse   342 NKATP-TCDTVMEMEYLDMVLNETLRLYPIVTRLERVCKKDVELNGVYIPKGSMVMIPSYALHHD 405

  Fly   444 PRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVD 508
            |:.:|.||:|.|:.|..||.....|:.|:||..|||||||.:||::..|..::.||:.:..:...
Mouse   406 PQHWPDPEEFQPERFSKENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQ 470

  Fly   509 RRE-DLTLLGELILRPKDGLRVKITPRD 535
            ..: .|.|..:.||:|:..:.:|:.|||
Mouse   471 ETQIPLKLSRQGILQPEKPIVLKVVPRD 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	CYP4V-like	96..529	CDD:410753	125/459 (27%)
Cyp3a44	NP_796354.1	CYP3A	67..493	CDD:410743	128/476 (27%)