DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	548	Identity:	153/548 - (27%)
Similarity:	267/548 - (48%)	Gaps:	86/548 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAI-------EMNVDHDE 79
            :.|..|..|:.||..||:.|..|..|...|.|. :.||||..:||||..:       :.:::..|
Mouse     3 LFSALSLDTLVLLAIILVLLYRYGTRTHGLFKK-QGIPGPKPLPFLGTVLNYYTGIWKFDMECYE 66

  Fly    80 LFNRVIGMQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNS---QKFVNKSHDYDYLHP--WL 139
            .:.      |.||       ::.|..|.:::.:|||::.:|..   ..|.|:..    ..|  .:
Mouse    67 KYG------KTWG-------LFDGQTPLLVITDPETIKNVLVKDCLSVFTNRRE----FGPVGIM 114

  Fly   140 GEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEAFNLFP-----Y 199
            .:.:..|.|.:|...|.:|:|.|....|.:...|..:...:|.:.|.    .||....|     .
Mouse   115 SKAISISKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLR----QEAEKGMPVAMKDV 175

  Fly   200 VTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDF----IFS------ 254
            :...::|::..|:.|..:.:.:|.|..:|:            :||.:|:.||    :||
Mouse   176 LGAYSMDVITSTSFGVNVDSLNNPEDPFVE------------EAKKFLRVDFFDPLLFSVVLFPL 228

  Fly   255 LTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLID 319
            ||..|::    :| :..|.|..|...|..:..:||:..::|           :|.|:.||.|:::
Mouse   229 LTPVYEM----LN-ICMFPNDSIEFFKKFVDRMQESRLDSN-----------QKHRVDFLQLMMN 277

  Fly   320 A---SKE---GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGD 378
            :   ||:   ....||.:|..:...|:..|::|||:.:|:||:.|..||:.|:::..|:|... .
Mouse   278 SHNNSKDKDSHKAFSNMEITVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKAL-P 341

  Fly   379 DKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRN 443
            :|.|| |...:|:|.||:..:.::|||:|.|..:.|:..:||.:.|..:|.|:..:|.:||||.:
Mouse   342 NKATP-TCDTVMEMEYLDMVLNETLRLYPIVTRLERVCKKDVELNGVYIPKGSMVMIPSYALHHD 405

  Fly   444 PRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVD 508
            |:.:|.||:|.|:.|..||.....|:.|:||..|||||||.:||::..|..::.||:.:..:...
Mouse   406 PQHWPDPEEFQPERFSKENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQ 470

  Fly   509 RRE-DLTLLGELILRPKDGLRVKITPRD 535
            ..: .|.|..:.||:|:..:.:|:.|||
Mouse   471 ETQIPLKLSRQGILQPEKPIVLKVVPRD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	136/505 (27%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	136/505 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810