DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and Cyp4ac1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_608916.1	Gene:	Cyp4ac1 / 33754	FlyBaseID:	FBgn0031693	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	188/524 - (35%)
Similarity:	290/524 - (55%)	Gaps:	42/524 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PITVFLLGSIL------IFLVVYNKR-----RSRLVKYIEKIPGPAAMPFLGNAIE-MNVDHDEL 80
            ||.:.:|..:|      .|::...||     .|.|...:..:||...   .||.:: :|.....:
  Fly     9 PILLAVLTLLLKHINKTYFILSLTKRVRTEDGSPLESKVAIMPGKTR---FGNNLDILNFTPASV 70

  Fly    81 FNRVIGMQKLWGTRIGINRVWQGT-APRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWLGEGLL 144
            ||.|   ::......|.|.:|... ||...:..||..|.:..|.|.:.|:..|:.:.|:||:|||
  Fly    71 FNFV---RESTAKAKGQNYLWYFLYAPMYNVVRPEEAEEVFQSTKLITKNVVYELIRPFLGDGLL 132

  Fly   145 TSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSA----VLARKLAVEVGSEAFNLFPYVTLCTL 205
            .|||.|||||||.|||||||.:|..|:.:|.|:..    ||.:.|..|:     .|...:...||
  Fly   133 ISTDHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNLDAEL-----ELNQVIPPFTL 192

  Fly   206 DIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLH 270
            :.:||||:|.::...|.. :||.||::.|..::..|.....:..::.|.:..:|:.|...:..:|
  Fly   193 NNICETALGVKLDDMSEG-NEYRKAIHAIEEVLIQRVCNPLMYYNWYFFVYGDYRKHLQNLRIVH 256

  Fly   271 GFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIREE 335
            .||:.:|..::.:....|...          .|:.|:|:|.|.||.|:.|..:|.: .::.|.:|
  Fly   257 DFSSRIIERKRQQFQQKQLGE----------VDEFGRKQRYAMLDTLLAAEADGQI-DHQGICDE 310

  Fly   336 VDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIK 400
            |:||||||:||||..:.:||.:|..|.:.|::..||::::..|..:  .:|.....:.||||.||
  Fly   311 VNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENLPEDSDD--ISMFQFNKLVYLECVIK 373

  Fly   401 DSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAG 465
            :|||:|||||.:.|...|:..:.|.::|..||..|..|.:.|:||.||||:.|.||.|||||...
  Fly   374 ESLRMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPKPDLFQPDRFLPENTVN 438

  Fly   466 RHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVK 530
            ||||||:|||||.||||||||||||.|.:::.|:|.:|:....:.||||....::||.::.::||
  Fly   439 RHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQENIKVK 503

  Fly   531 ITPR 534
            ::.|
  Fly   504 LSKR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	177/477 (37%)
Cyp4ac1	NP_608916.1	p450	86..504	CDD:278495	167/436 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460482
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm1194
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000