DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and Cyp6t1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	127/557 - (22%)
Similarity:	221/557 - (39%)	Gaps:	87/557 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKVITSLMAESILLSKVGQVISG--YSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMP 65
            |.:..:|...|::|..|  |:.|  ...:|:..|..||.|   ::.||.       .:|...|.|
  Fly     6 SLIAAALAVGSLVLLPV--VLRGGCLLVVTIVWLWQILHF---WHWRRL-------GVPFVPAAP 58

  Fly    66 FLGNAIEMNVDHDELFNRVIG-------MQKLWGTRIGINRVWQGT----APRVLLFEPETVEPI 119
            |:||          ::|.:.|       .::|:.::....|.:.|.    ...:||.:|..::.|
  Fly    59 FVGN----------VWNLLRGACCFGDQFRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRI 113

  Fly   120 LNSQKFVNKSHDYDYLHPWL----GEGLLTSTDRKWHSRRKILTPAF-------HFKILDDFIDV 173
            : .:.|...|..::...|..    .:.|..|....|....||..|.|       .:.:|::....
  Fly   114 M-VEDFAQFSSRFETTDPTCDTMGSQNLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQK 177

  Fly   174 FNEQSAVLARKLAVEVGSEAFNLFPYVTLC---TLDIVCETAMGRRIYAQSNSESEYVKAVYGIG 235
            ..|.   :.:||:   |.::..| ....||   |.||:...|.|...::..|.|:|:.:....:.
  Fly   178 LEEH---MEQKLS---GRDSMEL-EVKQLCALFTTDIIASLAFGIEAHSLQNPEAEFRRMCIEVN 235

  Fly   236 SIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPD 300
            .....|...::..  |.|...:    |:  :.| |.:|....|..:..:..:......:..|..|
  Fly   236 DPRPKRLLHLFTM--FFFPRLS----HR--VGT-HLYSEEYERFMRKSMDYVLSQRAESGENRHD 291

  Fly   301 AYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQ 365
            ..|        .||.|......|..:...:....:....:..|.||:|:.|::.|:.|..:...|
  Fly   292 LID--------IFLQLKRTEPAESIIHRPDFFAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQ 348

  Fly   366 ERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMAR----MVGEDVN--IGG 424
            :|:..||.:.....::...:...:..:.||...:.:.|||:|....:.|    ..|.|::  .||
  Fly   349 DRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGG 413

  Fly   425 K--IVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFA 487
            .  .:.|||...|....:||:.:.:|.||.|:|:.|..|.....||..|:||.||||.|||....
  Fly   414 SPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLG 478

  Fly   488 ILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPK 524
            .||.|..:..:|..:::|..:|     .|.|:...||
  Fly   479 QLEIKVGLLHILNHFRVEVCER-----TLPEMRFDPK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	113/499 (23%)
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	103/450 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010