DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp4g1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	188/556 - (33%)
Similarity:	311/556 - (55%)	Gaps:	28/556 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSKVITSLMAESILLSKVGQVISGYSPITVFLLGSIL-IFLVVYNKRRSRLVKYIEKIPGPAAM 64
            |:.:|:...:.::  .|.....:.|:||:...|:|::: :.|..|.:|.||..:.:..||.|..:
  Fly     1 MAVEVVQETLQQA--ASSSSTTVLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPEL 63

  Fly    65 PFLGNA-IEMNVDHDELFNRVIGMQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNK 128
            |.||.| :...:.:.|:....:|....:|..:   :.|.|....|.|..|..:|.||:..:.:.|
  Fly    64 PILGQAHVAAGLSNAEILAVGLGYLNKYGETM---KAWLGNVLLVFLTNPSDIELILSGHQHLTK 125

  Fly   129 SHDYDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEA 193
            :.:|.|..||.|:|||.|....|...||::.|.||..||..|:..|.:.|..:..::.:|.| ::
  Fly   126 AEEYRYFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEAG-KS 189

  Fly   194 FNLFPYVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAE 258
            |::..|::..|:||:..||||.:...:.|...||.:||..:..|:..||.|:..:.|.|:..|..
  Fly   190 FDVHDYMSQTTVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKL 254

  Fly   259 YKLHQSYINTLHGFSNMVIRERKAEL-----AILQENNN-------NNNNNAPDAYD-----DVG 306
            .:.....:|.:.|.::.|:::||...     ||::|.:.       :......|..|     |||
  Fly   255 REKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVG 319

  Fly   307 KKKRLAFLDLLIDASKEGTVLSNE-DIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVE 370
            .|:|||.||.:::.:|...:..|| ||.:||:|.||||||||||..|:.|.::|.|.:.|.:|..
  Fly   320 AKRRLALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFA 384

  Fly   371 ELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI--GGKIVPAGTQA 433
            |..:||||:.....|..:.|:|:|||..|.::|||:|.||::||.:..|:.:  |...||.||..
  Fly   385 EQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTV 449

  Fly   434 IIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTV 498
            |::.|.:||.|.::|.|.:|:|||||||..|.||.:::||||||||:|:|:|:|:|:.|.::||:
  Fly   450 IVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTI 514

  Fly   499 LRKYKIEAVDRREDLTLLGELILRPKDGLRVKITPR 534
            :|.|.:.:.|...|..|..::||:.::|..|.:..|
  Fly   515 VRNYIVHSTDTEADFKLQADIILKLENGFNVSLEKR 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	173/492 (35%)
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	165/463 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.070