DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp4a3

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_038965516.1	Gene:	Cyp4a3 / 298423	RGDID:	631356	Length:	511	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	172/521 - (33%)
Similarity:	277/521 - (53%)	Gaps:	46/521 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ITVFLLGSIL--IFLVVYNK-----RRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVIG 86
            ::.|..|:.|  :|||::..     ||..|:|.:||.|...:....|:.::     |..|.:|:
  Rat    15 VSGFFQGAFLLSLFLVLFKAVQFYLRRQWLLKALEKFPSTPSHWLWGHDLK-----DREFQQVL- 73

  Fly    87 MQKLWGTRI-GINRVW-QGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWL----GEGLLT 145
               .|..:. |....| .|:..||||::|:.|:.:| .:.....|..|.:|.||:    |.|||.
  Rat    74 ---TWVEKFPGACLQWLSGSKTRVLLYDPDYVKVVL-GRSDPKASGIYQFLAPWIVSGTGYGLLL 134

  Fly   146 STDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKL-AVEVGSEAFNLFPYVTLCTLDIVC 209
            ...:||....::||||||:.||..::.:..:..:::..|. .::.......:|.||:|.|||.|.
  Rat   135 LNGKKWFQHWRMLTPAFHYGILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVM 199

  Fly   210 ETAMGRR--IYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGF 272
            :.|...:  :....||.| |.|||..:.::...|....:..:..|::::::.:|.:......|..
  Rat   200 KCAFSHQGSVQLDVNSRS-YTKAVEDLNNLTFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEH 263

  Fly   273 SNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKE-GTVLSNEDIREEV 336
            ::.||:.|||:|...:|            .....||:.|.|||:|:.|..| |..||:||:|.||
  Rat   264 TDGVIKMRKAQLQNEEE------------LQKARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEV 316

  Fly   337 DTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKD 401
            |||||||||||::.|||..:.|..|||:|||..||:.||.||.  |..|..:|..:.|...|||:
  Rat   317 DTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDG--TSVTWDHLDQISYTTMCIKE 379

  Fly   402 SLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAG 465
            :|||:|.||.::|.:...|.. .|:.:|.|....|:.|.||.||..:|.|:.|:|..|.|:  :.
  Rat   380 ALRLYPPVPSVSRELSSPVTFPDGRSIPKGITTTILIYGLHHNPSYWPNPKVFDPSRFSPD--SP 442

  Fly   466 RHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVK 530
            ||..||:|||.|.|||||::||:.|.|..::..|.::::.....|..:. :..|:|:.|:|:.::
  Rat   443 RHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVP-MARLVLKSKNGIHLR 506

  Fly   531 I 531
            :
  Rat   507 L 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	160/482 (33%)
Cyp4a3	XP_038965516.1	CYP4B-like	69..506	CDD:410771	157/459 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348409
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750