DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001028858.2	Gene:	Cyp4f18 / 290623	RGDID:	1305261	Length:	524	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	177/527 - (33%)
Similarity:	278/527 - (52%)	Gaps:	46/527 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVIG 86
            ::.|.|.:..::|..  ::.|..|.||.|      :.|.|....:|...:.:....:|   .::.
  Rat    23 LLVGASCLLAYILPQ--VYAVFENSRRLR------RFPQPPTRNWLFGHLGLIQSSEE---GLLY 76

  Fly    87 MQKLWGTRIGINRVWQGT-APRVLLFEPETVEPILNSQKFVNKSHD--YDYLHPWLGEGLLTSTD 148
            :|.|..|...:...|.|. .|.:.:|.|..::|::.:...|.....  |.:|.||||:|||.||.
  Rat    77 IQSLSRTFRDVCCWWVGPWHPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLKPWLGDGLLLSTG 141

  Fly   149 RKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARK---LAVEVGSEAFNLFPYVTLCTLDIVCE 210
            .||...|.:|||||||.||..::.:||:.:.::..|   ||.: ||...::|.:::|.|||
  Rat   142 DKWSRHRHMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLASQ-GSARLDMFEHISLMTLD---- 201

  Fly   211 TAMGRRIYA-QSNSE---SEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHG 271
             ::.:.::: .||.:   |||:.|:..:.::|..|...:.|..|..:.||.:....:.....:|.
  Rat   202 -SLQKCVFSFDSNCQEKPSEYITAILELSALVARRHQSLLLYVDLFYHLTRDGMRFRKACRLVHD 265

  Fly   272 FSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLD-LLIDASKEGTVLSNEDIREE 335
            |::.|||||:..|.         :....||.....|.|.|.|:| ||:...:.|..||:||||.|
  Rat   266 FTDAVIRERRRTLP---------DQGGDDALKAKAKAKTLDFIDVLLLSKDEHGEALSDEDIRAE 321

  Fly   336 VDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIK 400
            .|||||.|||||::.:||.|:.|..|||||||..:|:..:..|.:.......:|..:.:|..|||
  Rat   322 ADTFMFGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIK 386

  Fly   401 DSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCA 464
            :||||.|....::|...:|:.: .|:::|.|....|..:..|.||.|:|.||.:||..|..:|..
  Rat   387 ESLRLHPPATAISRCCTQDIMLPDGRVIPKGVICRISIFGTHHNPAVWPDPEVYNPFRFDADNGE 451

  Fly   465 GRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVD---RREDLTLLGELILRPKDG 526
            ||.|.|:|||||||||||||.||:.|.|..::..|.::::...|   ||:.     |||||.:.|
  Rat   452 GRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRKP-----ELILRAEGG 511

  Fly   527 LRVKITP 533
            |.:::.|
  Rat   512 LWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	168/486 (35%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	164/460 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348451
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650