DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and Cyp4f4

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_775146.1	Gene:	Cyp4f4 / 286904	RGDID:	708363	Length:	522	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	181/545 - (33%)
Similarity:	283/545 - (51%)	Gaps:	82/545 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMP-FLGNAIEMNVDHDELFNRVI 85
            ::.|.|.:.|.:|....||...|        :::...|.|.... |||:               :
  Rat    23 LLIGASWLLVRVLTQTYIFYRTY--------QHLCDFPQPPKWNWFLGH---------------L 64

  Fly    86 GMQKLWGTRIGINRV-------------WQG-TAPRVLLFEPETVEPILNSQKFV--NKSHDYDY 134
            ||  :..|..|:.:|             |.| ..|.:.|..|:.:..:|::...|  .:...|.:
  Rat    65 GM--ITPTEQGLKQVTKLVATYPQGFMTWLGPILPIITLCHPDVIRSVLSASASVALKEVIFYSF 127

  Fly   135 LHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARK---LAVEVGSEAFNL 196
            |.||||:|||.|...||...|::|||||||.||..::.:||:.:.::..|   || ..||...::
  Rat   128 LKPWLGDGLLLSDGDKWSCHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQDLA-SGGSARLDM 191

  Fly   197 FPYVTLCTLDIVCETAMGRRIYA-QSNSE---SEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTA 257
            |..::|.|||     ::.:.::: .||.:   |||:.|:..:.::|..|..::.|.:|.::.||.
  Rat   192 FKNISLMTLD-----SLQKCVFSFDSNCQEKPSEYISAILELSALVAKRYQQLLLHTDSLYQLTH 251

  Fly   258 EYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDV----GKKKRLAFLD-LL 317
            ..:........:|.|::.||:.|:..|....|             ||:    .:.|.|.|:| ||
  Rat   252 NGRRFHKACKLVHNFTDAVIQGRRRALPSQHE-------------DDILKAKARSKTLDFIDVLL 303

  Fly   318 IDASKEGTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKET 382
            :...::|..||:||||.|.|||||||||||::.:||.|:.|..|||||||..:|:..:..|.:.|
  Rat   304 LTKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDREST 368

  Fly   383 PATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRV 446
            .....:|..:.:|..|||:||||.|.|.:::|...:|:.: .|:::|.|...||..:|.|.||.|
  Rat   369 EIEWDDLAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTV 433

  Fly   447 FPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVD--- 508
            :|.||.::|..|.|||...|.|.|:|||||||||||||.||:.|.|..::..|.::::...|
  Rat   434 WPDPEVYDPFRFDPENIKDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDKEP 498

  Fly   509 RREDLTLLGELILRPKDGLRVKITP 533
            ||:.     |||||.:.||.:::.|
  Rat   499 RRKP-----ELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	173/504 (34%)
Cyp4f4	NP_775146.1	CYP4F	74..515	CDD:410772	164/464 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348444
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650