DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and CYP4A22

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001010969.2	Gene:	CYP4A22 / 284541	HGNCID:	20575	Length:	519	Species:	Homo sapiens

Alignment Length:	530	Identity:	168/530 - (31%)
Similarity:	279/530 - (52%)	Gaps:	59/530 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ISGYSPITVFLLGSILIFLVVYNK------RRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELF 81
            :||...:|     |:||.|::..|      .|..|:|.:::.|.|.:....|:..|.  .||:..
Human    15 VSGILQVT-----SLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEF--QHDQEL 72

  Fly    82 NRVIGMQK---------LWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSH-DYDYLH 136
            .|:....|         :||.::           ||.|::|:.::.||....  .||| .|.:|.
Human    73 QRIQERVKTFPSACPYWIWGGKV-----------RVQLYDPDYMKVILGRSD--PKSHGSYKFLA 124

  Fly   137 PWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEA-FNLFPYV 200
            |.:|.|||....:.|...|::||||||..||..::.:..:...|:..|....:|.:: ..:|.:|
Human   125 PRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHV 189

  Fly   201 TLCTLDIVCETAMGRR--IYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQ 263
            :|.|||.:.::|...:  |....||:| |::|:..:.|:|.......:.::|.|:|||:..:...
Human   190 SLMTLDTIMKSAFSHQGSIQVDRNSQS-YIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTH 253

  Fly   264 SYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKE-GTVL 327
            ......|..::.||:.|||:   ||:...         .:.:.:|:.|.|||:|:.|..| |::|
Human   254 RACQLAHQHTDQVIQLRKAQ---LQKEGE---------LEKIKRKRHLDFLDILLLAKMENGSIL 306

  Fly   328 SNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDM 392
            |::|:|.|||||||||||||::.|||.|:.|..||::|||..||:..:.||.  ...|..:|..|
Human   307 SDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDG--ASITWNHLDQM 369

  Fly   393 RYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPD 456
            .|...|||::|||:|.||.:.|.:...|.. .|:.:|.|...::..|.||.||:|:|..|.|:|.
Human   370 PYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPS 434

  Fly   457 NFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELIL 521
            .|.|.  :.:|..|::|||.|.|||||::||:.:.|...:..|.::::.....|..:. :..|:|
Human   435 RFAPG--SAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIP-MARLVL 496

  Fly   522 RPKDGLRVKI 531
            :.|:|:.:::
Human   497 KSKNGIHLRL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	157/486 (32%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	157/485 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154675
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.640