DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	140/547 - (25%)
Similarity:	242/547 - (44%)	Gaps:	83/547 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QVISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVI 85
            ::|...|..|..||.:.|:...:|......|.|.: .||||..:|..|.          :||...
  Rat     2 EIIPNLSIETWVLLATSLMLFYIYGTYSHGLFKKL-GIPGPKPVPLFGT----------IFNYGD 55

  Fly    86 GM-----------QKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQ---KFVNKSHDYDYLH 136
            ||           .|:||       .::|..|.:.:.:||.::.:|..:   .|.|:.    ...
  Rat    56 GMWKFDDDCYKKYGKIWG-------FYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRR----CFG 109

  Fly   137 P--WLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKL-AVEVGSEAFNLFP 198
            |  ::.:.:..|.|.:|...|.||:|.|....|.:...:..:....|.:.| ..|...|..|:..
  Rat   110 PMGFMKKAITMSEDEEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREEAKGEPINMKD 174

  Fly   199 YVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFS------LTA 257
            .....::|::..|:.|..:.:.:|.:..:|:....|        .|..:...|:.|      ||.
  Rat   175 IFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKI--------LKFQIFDPFLLSVVLFPFLTP 231

  Fly   258 EYKLHQSYI---NTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLID 319
            .|::....|   .:::.|...|...:|..|                   |..:|.|:.||.|:::
  Rat   232 IYEMLNFSIFPRQSMNFFKKFVKTMKKNRL-------------------DSNQKSRVDFLQLMMN 277

  Fly   320 -----ASKEGTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDD 379
                 ..:....||:.::..:...|:|.|:|.||.:||:.::.|...|..|:::..|:|...  .
  Rat   278 TQNSKGQESQKALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRAL--P 340

  Fly   380 KETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNP 444
            .:.|.|...||:|.||:..:.:||||:|....:.|:..:||.|.|..:|.||...|..|.|||||
  Rat   341 NKAPVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEINGVFIPKGTVVTIPIYPLHRNP 405

  Fly   445 RVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDR 509
            ..:.:||:|||:.|..||.....|:.|:||..|||||||.:||::..|..:..||:.:.|:..::
  Rat   406 EYWLEPEEFNPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEK 470

  Fly   510 RE-DLTLLGELILRPKDGLRVKITPRD 535
            .: .|.:..:.|.:|:..:.:|:..||
  Rat   471 TQIPLKISRQPIFQPEGPIILKLVSRD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	127/503 (25%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	118/464 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810