DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp19a1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_058781.2	Gene:	Cyp19a1 / 25147	RGDID:	2457	Length:	503	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	123/577 - (21%)
Similarity:	229/577 - (39%)	Gaps:	150/577 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ITSLMAESILLSKVGQVISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNA 70
            :|.::.|::.:|.:        |: :.::|   :.|::.|...|      ..||||.....:|..
  Rat    13 VTIMVPETVPVSAM--------PL-LLIMG---LLLLIRNCESS------SSIPGPGYCLGIGPL 59

  Fly    71 IEMNVDHDELFNRVIG-----MQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNK-- 128
            |    .|.......||     ..|::|.   ..|||......:::.:..::..::....::::
  Rat    60 I----SHGRFLWMGIGSACNYYNKMYGE---FMRVWISGEETLIISKSSSMVHVMKHSNYISRFG 117

  Fly   129 ---------SHDYDYLHPWLGEGLLTSTDRK-WHSRR----KILT-PAF-------------HFK 165
                     .|:         .|::.:.:.. |.:.|    |.|| |..             |..
  Rat   118 SKRGLQCIGMHE---------NGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLD 173

  Fly   166 ILDD------FIDVFNEQSAVLARKLAVEVGSEAFNLFPYVTLCTLDIVCETAMGRRIYAQSNSE 224
            .|.|      ::||     ..|.|.:.::..:..|...|      ||                 |
  Rat   174 RLGDVTDNSGYVDV-----VTLMRHIMLDTSNTLFLGIP------LD-----------------E 210

  Fly   225 SEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQE 289
            |..||.:.|..:..|:    :.::.:..|.::..|:.::..:..|           |.|:.||.|
  Rat   211 SSIVKKIQGYFNAWQA----LLIKPNIFFKISWLYRKYERSVKDL-----------KDEIEILVE 260

  Fly   290 NNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSAAISWT 354
            ......::|....|      .:.|...||.|.:.|. |:.|::.:.:...:....||.|..:...
  Rat   261 KKRQKVSSAEKLED------CMDFATDLIFAERRGD-LTKENVNQCILEMLIAAPDTMSVTLYVM 318

  Fly   355 LFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGED 419
            |.|:..:||.:..:::|:.::.||.......::||   :.:|..|.:|||..|.|.::.|...||
  Rat   319 LLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNL---KVVENFINESLRYQPVVDLVMRRALED 380

  Fly   420 VNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYI-PFSAGPRNCIG 483
            ..|.|..|..||..|:....:|| ...||||.:|..:|| .:|.    |:.|. ||..|||:|.|
  Rat   381 DVIDGYPVKKGTNIILNIGRMHR-LEYFPKPNEFTLENF-EKNV----PYRYFQPFGFGPRSCAG 439

  Fly   484 QKFAILEEKAVISTVLRKYKIEAVDRR--------EDLTL-------LGELILRPKD 525
            :..|::..|.|:.|:|:::.::.:.:|        .||:|       :.|:|..|::
  Rat   440 KYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLHLDEDSPIVEIIFSPRN 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	114/524 (22%)
Cyp19a1	NP_058781.2	CYP19A1	72..485	CDD:410709	103/483 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348457
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950