Protein Alignment Cyp4c3 and Cyp19a1

DIOPT Version :10

• Sequence 1: NP_524598.1
• Gene: Cyp4c3 / 43663
• FlyBaseID: FBgn0015032
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_058781.2
• Gene: Cyp19a1 / 25147
• RGDID: 2457
• Length: 503
• Species: Rattus norvegicus
• Alignment Length: 577
• Identity: 123/577 - (21%)
• Similarity: 229/577 - (39%)
• Gaps: 150/577 - (25%)

  Fly     6 ITSLMAESILLSKVGQVISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNA 70
            :|.::.|::.:|.:        |: :.::|   :.|::.|...|      ..||||.....:|..
  Rat    13 VTIMVPETVPVSAM--------PL-LLIMG---LLLLIRNCESS------SSIPGPGYCLGIGPL 59

  Fly    71 IEMNVDHDELFNRVIG-----MQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNK-- 128
            |    .|.......||     ..|::|.   ..|||......:::.:..::..::....::::
  Rat    60 I----SHGRFLWMGIGSACNYYNKMYGE---FMRVWISGEETLIISKSSSMVHVMKHSNYISRFG 117

  Fly   129 ---------SHDYDYLHPWLGEGLLTSTDRK-WHSRR----KILT-PAF-------------HFK 165
                     .|:         .|::.:.:.. |.:.|    |.|| |..             |..
  Rat   118 SKRGLQCIGMHE---------NGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLD 173

  Fly   166 ILDD------FIDVFNEQSAVLARKLAVEVGSEAFNLFPYVTLCTLDIVCETAMGRRIYAQSNSE 224
            .|.|      ::||     ..|.|.:.::..:..|...|      ||                 |
  Rat   174 RLGDVTDNSGYVDV-----VTLMRHIMLDTSNTLFLGIP------LD-----------------E 210

  Fly   225 SEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQE 289
            |..||.:.|..:..|:    :.::.:..|.::..|:.::..:..|           |.|:.||.|
  Rat   211 SSIVKKIQGYFNAWQA----LLIKPNIFFKISWLYRKYERSVKDL-----------KDEIEILVE 260

  Fly   290 NNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSAAISWT 354
            ......::|....|      .:.|...||.|.:.|. |:.|::.:.:...:....||.|..:...
  Rat   261 KKRQKVSSAEKLED------CMDFATDLIFAERRGD-LTKENVNQCILEMLIAAPDTMSVTLYVM 318

  Fly   355 LFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGED 419
            |.|:..:||.:..:::|:.::.||.......::||   :.:|..|.:|||..|.|.::.|...||
  Rat   319 LLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNL---KVVENFINESLRYQPVVDLVMRRALED 380

  Fly   420 VNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYI-PFSAGPRNCIG 483
            ..|.|..|..||..|:....:|| ...||||.:|..:|| .:|.    |:.|. ||..|||:|.|
  Rat   381 DVIDGYPVKKGTNIILNIGRMHR-LEYFPKPNEFTLENF-EKNV----PYRYFQPFGFGPRSCAG 439

  Fly   484 QKFAILEEKAVISTVLRKYKIEAVDRR--------EDLTL-------LGELILRPKD 525
            :..|::..|.|:.|:|:::.::.:.:|        .||:|       :.|:|..|::
  Rat   440 KYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLHLDEDSPIVEIIFSPRN 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	CYP4V-like	96..529	CDD:410753	104/482 (22%)
Cyp19a1	NP_058781.2	CYP19A1	72..485	CDD:410709	103/483 (21%)