DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4c3 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_663708.1	Gene:	Cyp4x1 / 246767	RGDID:	628719	Length:	507	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	167/528 - (31%)
Similarity:	263/528 - (49%)	Gaps:	66/528 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVIGMQKLWGTRI 95
            ||.|..:|:..|....||.||::.:...|||.|...||:...:..|:.|..:.::   |.:....
  Rat    19 VFCLALVLMQAVKLYLRRQRLLRDLRPFPGPTAHWLLGHQKFLQEDNMEKLDEIV---KEYPCAF 80

  Fly    96 GINRVWQGTAPRVL-LFEPETVEPILNSQKFVNKSHDYDYLH----PWLGEGLLTSTDRKWHSRR 155
               ..|.|...... :::|:..:..|:     .......|||    |:||.|||.....:|...|
  Rat    81 ---PCWVGPFQAFFYIYDPDYAKIFLS-----RTDPKTQYLHQLMTPFLGRGLLNLDGPRWFQHR 137

  Fly   156 KILTPAFHFKILDDFIDVFNEQSAVL---------ARKLAVEVGSEAFNLFPYVTLCTLDIVCET 211
            .:||||||..||...:|:......::         .::..:||       |.::.|.||||:.:.
  Rat   138 CLLTPAFHQDILKPCVDMMAHSVNMMLDKWEKTWTTQETTIEV-------FEHINLMTLDIIMKC 195

  Fly   212 AMGRRIYAQSNSESE-YVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNM 275
            |.|:....|.|...| ||||.:.:|.|:.||....|...|.||.|:.:....|.....:|..:..
  Rat   196 AFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQCTEK 260

  Fly   276 VIRERKAEL--AILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDA-SKEGTVLSNEDIREEVD 337
            :|::||..|  .:.|::...:.|                |||:::.| :.:....|:.|:|.||:
  Rat   261 IIQDRKKTLKDQVNQDDTQTSQN----------------FLDIVLSAQAGDEKAFSDADLRSEVN 309

  Fly   338 TFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDS 402
            |||:.|||.::|:|||.|:.|..:||:|:|...|:.||.||.  :..|.:.|.::.|...|||::
  Rat   310 TFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDG--SSITWEQLDEIPYTTMCIKET 372

  Fly   403 LRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGR 466
            |||.|.:|.::|.:.:.:.: .|..:|||...::..:.||.||.|:..|:.|:|..|..||...|
  Rat   373 LRLIPPIPSISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWKDPKVFDPLRFTKENSEQR 437

  Fly   467 HPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLT----LLGELILRPKDG- 526
            ||.|::|||:||||||||:||:||.|..|:..|.::::.|     |||    .....:||||.|
  Rat   438 HPCAFLPFSSGPRNCIGQQFAMLELKVAIALTLLRFRVAA-----DLTRPPAFSSHTVLRPKHGI 497

  Fly   527 -LRVKITP 533
             |.:|..|
  Rat   498 YLHLKKLP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	156/496 (31%)
Cyp4x1	NP_663708.1	CYP4B-like	66..500	CDD:410771	148/474 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348418
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750