DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	174/538 - (32%)
Similarity:	281/538 - (52%)	Gaps:	63/538 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LSKVGQVISGYSPITVFLLGSILIFLVVYNK------RRSRLVKYIEKIPGPAAMPFLGNAIEMN 74
            ||::|            |..|::|.:|:..|      ||.:|.:.::..|||......|:|:|
  Rat    10 LSRLG------------LWASVVILMVIVLKLFSLLLRRQKLARAMDSFPGPPTHWLFGHALE-- 60

  Fly    75 VDHDELFNRVIGMQKL--------WGTRI-GINRVWQGTAPRVL-LFEPETVEPILNSQKFVNKS 129
                        :|||        |..:. ..:.:|.|.....| ::||:..:.:.:  :...|:
  Rat    61 ------------IQKLGSLDKVVSWAQQFPHAHPLWFGQFVGFLNIYEPDYAKAVYS--RGDPKA 111

  Fly   130 HD-YDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVG-SE 192
            .| ||:...|:|:|||.....||...||:|||.||:.:|..::.:|.|.:.::..|...:.. ::
  Rat   112 ADVYDFFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENK 176

  Fly   193 AFNLFPYVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTA 257
            :|::|..|....||.:.:...|:......:.::.|..||..:..::|.|.......:|||:.||.
  Rat   177 SFDIFCDVGHMALDTLMKCTFGKGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTP 241

  Fly   258 EYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASK 322
            ..:.........|..::.|||:|||.|...:|...            :.:::.|.|||:|:....
  Rat   242 HGRRFLRACKIAHDHTDEVIRQRKAALQDEKERKK------------IQQRRHLDFLDILLGVRD 294

  Fly   323 E-GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATM 386
            | |..||:.::|.|||||||||||||::.|||.|:.:..:||:|:...||:..|.||  :.....
  Rat   295 ESGIKLSDAELRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGD--QDSFQW 357

  Fly   387 KNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVN-IGGKIVPAGTQAIIMTYALHRNPRVFPKP 450
            .:|..|.||..|:|:..||:|.||.:.|.:.:.|. :.|:.:|||:...:..||||||..|:|.|
  Rat   358 DDLAKMTYLTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRSLPAGSLISLHIYALHRNSTVWPDP 422

  Fly   451 EQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTL 515
            |.|:|..|.|||.|||||||::||||||||||||:||:.|.|.|.:..|.:::. ::|..:....
  Rat   423 EVFDPLRFSPENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEF-SLDPSKMPIK 486

  Fly   516 LGELILRPKDGLRVKITP 533
            :.:||||.|:|:.:.:.|
  Rat   487 VPQLILRSKNGIHLYLKP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	162/485 (33%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	162/483 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348454
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650