DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4c3 and Cyp4a29

DIOPT Version :9

Sequence 1:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001093653.1	Gene:	Cyp4a29 / 230639	MGIID:	3717143	Length:	509	Species:	Mus musculus

Alignment Length:	530	Identity:	156/530 - (29%)
Similarity:	269/530 - (50%)	Gaps:	56/530 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ISGYSPI-----------TVFLLGSILIFL--VVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMN 74
            ||..|||           .:||:|.:|:..  ..:..||..|::.:.:.|.|.:....|:.::..
Mouse     3 ISALSPIRFLECVSGFLQVIFLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGHCLQFK 67

  Fly    75 VDHD--------ELFNRVIGMQKLWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHD 131
            ||.:        |.|.... :..:||:.:.|.           :.:|:.::.||.  :...|:..
Mouse    68 VDEELRWILRYLEKFPGAF-LHWIWGSHVFIK-----------VCDPDYMKVILG--RADPKASL 118

  Fly   132 YDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKL-AVEVGSEAFN 195
            |.:|.||||.||......:|...|::||||||:.||..::.:..:...|:..|. .:........
Mouse   119 YRFLTPWLGHGLFFLNGDEWFQHRRLLTPAFHYDILKPYVGIMADSVQVMLEKWEQIACQDITLE 183

  Fly   196 LFPYVTLCTLDIVCETAMGRRIYAQSNSESE-YVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEY 259
            :|..::|..||.:.:.|...:...|.:..|: |::||..:.::|.||...::|.:|.|::||:..
Mouse   184 IFHPISLMMLDTIMKYAFSYQGSVQLDRSSQAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLTSHS 248

  Fly   260 KLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLD-LLIDASKE 323
            :...|.....|..::.|::.|||:   ||:|.:...         :..|:.|.||| ||:....:
Mouse   249 RRTNSACQIAHEHTDRVVKLRKAQ---LQDNKSMKK---------LRGKRCLDFLDILLLSRMDD 301

  Fly   324 GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKN 388
            |:.||::.:|.|||:.||.||||.::.|||..:.|..||::|:|..||:.|:.||.  :|.|..:
Mouse   302 GSSLSDKALRAEVDSLMFGGHDTPASGISWVFYALATHPDHQQRCREEVQSLLGDG--SPITWDH 364

  Fly   389 LMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVFPKPEQ 452
            |..|.|...|||::|||:|.:|.:.|.:...|.. .|:.:|.|...::..||||.||:|:|.||.
Mouse   365 LHQMPYTTMCIKEALRLYPPIPSVGRKLSTPVTFPDGRSLPKGITVLLHFYALHHNPKVWPNPEV 429

  Fly   453 FNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLG 517
            |:|..|...:.  :|..|::|||.|.|||||:..|:...|..::..|.::::.....|..:. ..
Mouse   430 FDPSRFAMNSV--QHSHAFLPFSGGSRNCIGKHLAMNVLKVAVALTLLRFELLPDPSRVPIP-TQ 491

  Fly   518 ELILRPKDGL 527
            :|:|:.|:|:
Mouse   492 QLVLKSKNGI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	144/481 (30%)
Cyp4a29	NP_001093653.1	p450	52..503	CDD:278495	144/481 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844964
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650